Gut Liver.  2013 Jul;7(4):385-393.

Chemotherapy for Advanced Gastric Cancer: Review and Update of Current Practices

• Park SC
• Chun HJ

Abstract

No standard adjuvant or palliative chemotherapy regimen has been internationally approved for patients with advanced gastric cancer. Adjuvant chemoradiotherapy is administered prior to surgery and is used in the Unitied States, and intensified chemotherapy is administered prior to and after surgery and is used in Europe. Limited D1 dissections are also frequently performed in the United States and Europe. In Korea, patients undergoing D2 resection appear to benefit from postoperative adjuvant chemotherapy using S-1 or capecitabine plus oxaliplatin. Fluoropyrimidine, platinum, taxane, epirubicin, and irinotecan may be employed alone or in combination as a first-line therapy in a palliative chemotherapy regimen. In Asia, an orally administered fluoropyrimidine, such as capecitabine or S-1, is favored over the continuous infusion of 5-fluorouracil because of its convenience. Trastuzumab has been integrated into the current standard chemotherapy for human epidermal growth factor receptor 2-overexpressing gastric cancers. There is currently no standard regimen for secondary palliative chemotherapy. Clinical studies of several targeted therapies are ongoing.

Keyword

Stomach neoplasms; Drug therapy

MeSH Terms

Antibodies, Monoclonal, Humanized
Asia
Bridged Compounds
Camptothecin
Chemoradiotherapy, Adjuvant
Chemotherapy, Adjuvant
Deoxycytidine
Epirubicin
Europe
Fluorouracil
Humans
Korea
Organoplatinum Compounds
Platinum
Receptor, Epidermal Growth Factor
Stomach Neoplasms
Taxoids
United States
Antibodies, Monoclonal, Humanized
Bridged Compounds
Camptothecin
Deoxycytidine
Epirubicin
Fluorouracil
Organoplatinum Compounds
Platinum
Receptor, Epidermal Growth Factor
Taxoids