Cancer Res Treat.  2008 Sep;40(3):101-105.

Phase II Study of Gemcitabine plus Cisplatin in Patients with Anthracycline- and Taxane- Pretreated Metastatic Breast Cancer

Affiliations
  • 1Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. kimhj@dau.ac.kr
  • 2Department of Pathology, Dong-A University College of Medicine, Busan, Korea.
  • 3Department of Diagnostic Radiology, Dong-A University College of Medicine, Busan, Korea.
  • 4Department of Radiation Oncology, Dong-A University College of Medicine, Busan, Korea.
  • 5Department of Surgery, Dong-A University College of Medicine, Busan, Korea.

Abstract

PURPOSE: Metastatic breast cancer patients are usually exposed to taxane and anthracycline as neoadjuvant, adjuvant and palliative chemotherapeutic agents. This study was designed to determine the efficacy and safety of the use of a gemcitabine and cisplatin (GP) combination treatment in patients with metastatic breast cancer that were pretreated with anthracycline and taxane.
MATERIALS AND METHODS
We evaluated the use of a GP regimen (1,000 mg/m2 gemcitabine administered on days 1 and 8 plus 60 mg/m2 cisplatin administered on day 1 every 3 weeks) in 38 breast cancer patients who had received prior chemotherapy with anthracycline and taxane as an adjuvant or neoadjuvant therapy, or as a palliative therapy.
RESULTS
The median patient age was 49 years (age range, 35~69 years). The overall response rate was 28.9% in 11 patients (95% confidence interval [CI], 14~44%). The median time to progression was 5.2 months (95% CI, 3.6~6.8 months). Median survival was 19.5 months (95% CI, 11.2~27.8 months). Major grade 3/4 hematological toxicity was due to leukopenia (36 of 157 cycles, 23.1%). Non-hematological toxicity was rarely severe; grade1/2 nausea and vomiting were observed in 37.8% of the patients. There were no treatment related deaths.
CONCLUSIONS
Our results suggest that the use of gemcitabine plus cisplatin appears to be effective and has an acceptable toxicity profile in patients with advanced breast cancer that have been pretreated with anthracycline and taxane.

Keyword

Breast neoplasms; Anthracycline; Taxane; Gemcitabine; Cisplatin

MeSH Terms

Breast
Breast Neoplasms
Bridged Compounds
Cisplatin
Deoxycytidine
Humans
Leukopenia
Nausea
Neoadjuvant Therapy
Taxoids
Vomiting
Bridged Compounds
Cisplatin
Deoxycytidine
Taxoids

Figure

  • Fig. 1 A demonstration of the time to progression of the patients. The median TTP was 5.2 months (95% CI; 3.6~6.8 months).

  • Fig. 2 The overall survival of patients. The median OS was 19.5 months (95% CI; 11.2~27.8 months).


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