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Upregulation of VEGF and FGF2 in Normal Rat Brain after Experimental Intraoperative Radiation Therapy

Kim JH, Chung YG, Kim CY, Kim HK, Lee HK

The expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF)2 in the irradiated brain was examined to test how a single high dose radiation, similar to that...
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Protective Effect of Hypoxic Preconditioning on Hypoxic-Ischemic Injured Newborn Rats

Park HK, Seol IJ, Kim KS

Brief episodes of cerebral hypoxia-ischemia cause transient ischemic tolerance to subsequent ischemic events that are otherwise lethal. This study was conducted to evaluate the protective effect of hypoxic preconditioning on...
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Primary Central Nervous System ALK Positive Anaplastic Large Cell Lymphoma with Predominantly Leptomeningeal Involvement in an Adult

Park JS, Park H, Park S, Kim SJ, Seol HJ, Ko YH

A 31-year-old Korean male presented with altered consciousness and severe headache. Brain MRI delineated focal leptomeningeal enhancement without any intracerebral lesions. Diagnosis was made based on a brain biopsy showing...
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Caveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing

Kang MJ, Chung YH, Hwang CI, Murata M, Fujimoto T, Mook-Jung , Cha CI, Park WY

  • KMID: 1111405
  • Exp Mol Med.
  • 2006 Apr;38(2):126-133.
Lipid rafts provide a platform for regulating cellular functions and participate in the pathogenesis of several diseases. However, the role of caveolin-1 in this process has not been elucidated definitely...
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Diverse Molecular Targets for Therapeutic Strategies in Alzheimer's Disease

Han SH, Mook-Jung

Alzheimer's disease (AD) is the most common form of dementia caused by neurodegenerative process and is tightly related to amyloid beta (Abeta) and neurofibrillary tangles. The lack of early diagnostic...
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Quantitative in Vivo Detection of Brain Cell Death after Hypoxia Ischemia Using the Lipid Peak at 1.3 ppm of Proton Magnetic Resonance Spectroscopy in Neonatal Rats

Ahn SY, Yoo HS, Lee JH, Sung DK, Jung YJ, Sung SI, Lim KH, Chang YS, Lee JH, Kim KS, Park WS

This study was performed to determine the accuracy of proton magnetic spectroscopy (1H-MRS) lipid peak as a noninvasive tool for quantitative in vivo detection of brain cell death. Seven day-old...
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Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical and histopathological findings

Kang BT, Lee JH, Jung DI, Park C, Gu SH, Jeon HW, Jang DP, Lim CY, Quan FS, Kim YB, Cho ZH, Woo EJ, Park HM

The aim of the present study was to assess the clinical and histopathological findings in a canine model of ischemic stroke. Cerebral ischemic stroke was induced by middle cerebral artery...
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