- Honokiol ameliorates endothelial dysfunction through suppression of PTX3 expression, a key mediator of IKK/IkappaB/NF-kappaB, in atherosclerotic cell model
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Qiu L, Xu R, Wang S, Li S, Sheng H, Wu J, Qu Y
- KMID: 2155425
- Exp Mol Med.
- 2015 Jul;47(7):e171.
- doi: 10.1038/emm.2015.37
Pentraxin 3 (PTX3) was identified as a marker of the inflammatory response and overexpressed in various tissues and cells related to cardiovascular disease. Honokiol, an active component isolated from the... -
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- A Novel Angiotensin Type I Receptor Antagonist, Fimasartan, Prevents Doxorubicin-induced Cardiotoxicity in Rats
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Chang SA, Lim BK, Lee YJ, Hong MK, Choi JO, Jeon ES
- KMID: 2155468
- J Korean Med Sci.
- 2015 May;30(5):559-568.
- doi: 10.3346/jkms.2015.30.5.559
Angiotensin receptor blockers (ARBs) have organ-protective effects in heart failure and may be also effective in doxorubicin-induced cardiomyopathy (DOX-CMP); however, the efficacy of ARBs on the prevention of DOX-CMP have... -
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- Cardioprotective Effect of Fimasartan, a New Angiotensin Receptor Blocker, in a Porcine Model of Acute Myocardial Infarction
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Sim DS, Jeong MH, Song HC, Kim J, Chong A, Bom HS, Jeong IS, Oh SG, Kim JM, Park DS, Kim JH, Lim KS, Kim MS, Ryu SH, Kim HK, Kim SS, Jang SY, Cho JY, Jeong HC, Lee KH, Park KH, Yoon NS, Yoon HJ, Kim KH, Hong YJ, Park HW, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC
- KMID: 2155445
- J Korean Med Sci.
- 2015 Jan;30(1):34-43.
- doi: 10.3346/jkms.2015.30.1.34
Cardioprotective effect of fimasartan, a new angiotensin receptor blocker (ARB), was evaluated in a porcine model of acute myocardial infarction (MI). Fifty swine were randomized to group 1 (sham, n=10),... -
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- Study on antioxidative, antidiabetic and antiobesity activity of solvent fractions of smilax china L. leaf extract
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Kang YH, Lee YS, Kim KK, Kim DJ, Kim TW, Choe M
- KMID: 2327120
- J Nutr Health.
- 2013 Oct;46(5):401-409.
Smilax china L., a native plant found in Asian countries, has several medicinal properties including antioxidant, anti-inflammatory, and anti-cancer effects. Although the root of the plant is commonly used as... -
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- Comparison of antioxidant, alpha-glucosidase inhibition and anti-inflammatory activities of the leaf and root extracts of Smilax china L.
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Kim KK, Kang YH, Kim DJ, Kim TW, Choe M
- KMID: 2327113
- J Nutr Health.
- 2013 Aug;46(4):315-323.
This study was conducted in order to compare the biological activities of leaf and root water extracts of Smilax china L. (SC) by measuring the total polyphenol and flavonoid contents,... -
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- Peroxisome proliferator-activated receptor gamma agonist suppresses human telomerase reverse transcriptase expression and aromatase activity in eutopic endometrial stromal cells from endometriosis
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Chang HJ, Lee JH, Hwang KJ, Kim MR, Yoo JH
- KMID: 1493212
- Clin Exp Reprod Med.
- 2013 Jun;40(2):67-75.
- doi: 10.5653/cerm.2013.40.2.67
OBJECTIVE: To investigate the effect of peroxisome proliferator activated receptor gamma (PPARgamma) agonist on the cell proliferation properties and expression of human telomerase reverse transcriptase (hTERT) and aromatase in cultured... -
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- Prenatal Exposures to Environmental Chemicals and Children's Neurodevelopment: An Update
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Bellinger
- KMID: 2317077
- Saf Health Work.
- 2013 Mar;4(1):1-11.
This review surveys the recent literature on the neurodevelopmental impacts of chemical exposures during pregnancy. The review focuses primarily on chemicals of recent concern, including phthalates, bisphenol-A, polybrominated diphenyl ethers,... -
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- Influence of Fimasartan (a Novel AT1 Receptor Blocker) on Catecholamine Release in the Adrenal Medulla of Spontaneously Hypertensive Rats
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Lim HJ, Lee SK, Lim DY
- KMID: 1432769
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):99-109.
- doi: 10.4196/kjpp.2013.17.1.99
The aim of this study was to determine whether fimasartan, a newly developed AT1 receptor blocker, can affect the CA release in the isolated perfused model of the adrenal medulla... -
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- Carbohydrase inhibition and anti-cancerous and free radical scavenging properties along with DNA and protein protection ability of methanolic root extracts of Rumex crispus
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Shiwani S, Singh NK, Wang MH
- KMID: 2313620
- Nutr Res Pract.
- 2012 Oct;6(5):389-395.
The study elucidated carbohydrase inhibition, anti-cancerous, free radical scavenging properties and also investigated the DNA and protein protection abilities of methanolic root extract of Rumex crispus (RERC). For this purpose,... -
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- The Influence of Antioxidant Resveratrol on Paraquat-induced Oxidative Stress in Cultured Lung Cells
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Baek KM, Lee SW, Park JS, Min JH, Hwang G, Do H, Kim H
- KMID: 2333153
- J Korean Soc Emerg Med.
- 2012 Aug;23(4):543-550.
PURPOSE: Paraquat (1,1'-dimethy-4,4'-bipyridinium dichloride, PQ) is an effective and widely used herbicide, which was introduced commercially in 1962. It is reduced by an electron donor, such as NADPH, and then... -
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- Mushrooms Collected from Deogyu Mountain, Muju, Korea and Their Antioxidant Activity
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Kim SE, Lee IK, Jung YA, Yeom JH, Ki DW, Lee MS, Song JG, Jin YJ, Seok SJ, Yun BS
- KMID: 2052903
- Mycobiology.
- 2012 Jun;40(2):134-137.
- doi: 10.5941/MYCO.2012.40.2.134
Mushrooms collected from Deogyu mountain, Korea, in 2011, were identified as four classes, four orders, 13 families, 22 genera, and 33 species. In particular, agaricales was most abundant and comprised... -
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- Diversity and Biological Activities of Endophytic Fungi of Emblica officinalis, an Ethnomedicinal Plant of India
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Nath A, Raghunatha P, Joshi SR
- KMID: 2408206
- Mycobiology.
- 2012 Mar;40(1):8-13.
In the present study, an attempt to evaluate the antimicrobial and antioxidant activity of fungal endophytes inhabiting Emblica officinalis has been made keeping in view the medicinal importance of the... -
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- Assessment of Antioxidant and Phenolic Compound Concentrations as well as Xanthine Oxidase and Tyrosinase Inhibitory Properties of Different Extracts of Pleurotus citrinopileatus Fruiting Bodies
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Alam N, Yoon KN, Lee KR, Kim HY, Shin PG, Cheong JC, Yoo YB, Shim MJ, Lee MW, Lee TS
- KMID: 2312605
- Mycobiology.
- 2011 Mar;39(1):12-19.
Cellular damage caused by reactive oxygen species has been implicated in several diseases, thus establishing a significant role for antioxidants in maintaining human health. Acetone, methanol, and hot water extracts... -
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- 5-Formylhonokiol exerts anti-angiogenesis activity via inactivating the ERK signaling pathway
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Zhu W, Fu A, Hu J, Wang T, Luo Y, Peng M, Ma Y, Wei Y, Chen L
- KMID: 1109403
- Exp Mol Med.
- 2011 Mar;43(3):146-152.
- doi: 10.3858/emm.2011.43.3.017
Our previous report has demonstrated that 5-formylhonokiol (FH), a derivative of honokiol (HK), exerts more potent anti-proliferative activities than honokiol in several tumor cell lines. In present study, we first... -
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- Anti-inflammatory and Anti-oxidative Effects of Korean Red Ginseng Extract in Human Keratinocytes
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Hong CE, Lyu SY
- KMID: 2150691
- Immune Netw.
- 2011 Feb;11(1):42-49.
- doi: 10.4110/in.2011.11.1.42
BACKGROUND: In this study, we have investigated the effect of Korean red ginseng (KRG) extracts on the production of TNF-alpha and IL-8 in human keratinocytes. Also, to examine the antioxidative... -
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- Antioxidant Activities and Tyrosinase Inhibitory Effects of Different Extracts from Pleurotus ostreatus Fruiting Bodies
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Alam N, Yoon KN, Lee KR, Shin PG, Cheong JC, Yoo YB, Shim JM, Lee MW, Lee UY, Lee TS
- KMID: 2312593
- Mycobiology.
- 2010 Dec;38(4):295-301.
We evaluated the antioxidant activity and tyrosinase inhibitory effects of Pleurotus ostreatus fruiting bodies extracted with acetone, methanol, and hot water. The antioxidant activities were tested against beta-carotene-linoleic acid, reducing... -
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- Antioxidative and Antidiarrheal Effects of Persimmon Extracts
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Park D, Lee SH, Bae DK, Cho YJ, Kim TK, Yang YH, Yang G, Kwon SC, Lee DI, Joo SS, Kim YB
- KMID: 2114710
- Lab Anim Res.
- 2010 Dec;26(4):407-413.
- doi: 10.5625/lar.2010.26.4.407
Since oxidative stresses are involved in gastroenteritis and diarrhea, we investigated antioxidative and antidiarrheal activities of persimmon flesh extract (PFE) and persimmon calyx extract (PCE) in vitro and in vivo,... -
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- Biological Activity and Single Oral Dose Toxicity of Dansam-samultang
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Lee IC, Kim BH, Kim MK
- KMID: 2114707
- Lab Anim Res.
- 2010 Dec;26(4):385-391.
- doi: 10.5625/lar.2010.26.4.385
In this study, we investigated the in vitro antioxidative effects, antimicrobial activities and single oral dose toxicity of the extracts from Dansam-samultang to evaluate its use as a functional ingredient... -
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- Magnolol Inhibits LPS-induced NF-kappaB/Rel Activation by Blocking p38 Kinase in Murine Macrophages
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Li MH, Kothandan , Cho SJ, Huong PT, Nan YH, Lee KY, Shin SY, Yea SS, Jeon YJ
- KMID: 2071705
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):353-358.
- doi: 10.4196/kjpp.2010.14.6.353
This study demonstrates the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to inhibit LPS-induced expression of iNOS gene and activation of NF-kappaB/Rel in RAW 264.7 cells.... -
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- In vivo Radiosensitization Effect of HDAC Inhibitor, SK-7041 on RIF-1 Cell Line
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Chie EK, Shin JH, Kim IA, Kim IH
- KMID: 1460139
- J Korean Soc Ther Radiol Oncol.
- 2010 Dec;28(4):219-223.
- doi: 10.3857/jkstro.2010.28.4.219
PURPOSE: To test the radiosensitizing effect of the newly synthesized novel histone deacetylase inhibitor, SK-7041 in vivo. MATERIALS AND METHODS: The RIF-1 cell line was implanted into the back of a... -
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