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Comparison of antigenic mutation during egg and cell passage cultivation of H3N2 influenza virus

Park YW, Kim YH, Jung HU, Jeong OS, Hong EJ, Kim H, Lee JI

PURPOSE: When influenza viruses are cultured in eggs, amino acid mutations of the hemagglutinin may occur through egg adaptation. On the other hand, when influenza viruses are cultured in animal...
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Molecular characterization of Plasmodium juxtanucleare in Thai native fowls based on partial cytochrome C oxidase subunit I gene

Pohuang T, Junnu S

Avian malaria is one of the most important general blood parasites of poultry in Southeast Asia. Plasmodium (P.) juxtanucleare causes avian malaria in wild and domestic fowl. This study aimed...
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Previous Infection with Plasmodium berghei Confers Resistance to Toxoplasma gondii Infection in Mice

Lee DH, Chu KB, Kang HJ, Lee SH, Quan FS

Both Plasmodium spp. and Toxoplasma gondii are important apicomplexan parasites, which infect humans worldwide. Genetic analyses have revealed that 33% of amino acid sequences of inner membrane complex from the...
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Recent progress in laboratory diagnosis of thalassemia and hemoglobinopathy: a study by the Korean Red Blood Cell Disorder Working Party of the Korean Society of Hematology

Lee YK, Kim HJ, Lee K, Park SH, Song SH, Seong MW, Kim M, Han JY

Genetic hemoglobin disorders are caused by mutations and/or deletions in the α-globin or β-globin genes. Thalassemia is caused by quantitative defects and hemoglobinopathies by structural defect of hemoglobin. The incidence...
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Functional Prediction of Hypothetical Proteins from Shigella flexneri and Validation of the Predicted Models by Using ROC Curve Analysis

Gazi MA, Mahmud S, Fahim SM, Kibria MG, Palit P, Islam MR, Rashid H, Das S, Mahfuz M, Ahmeed T

Shigella spp. constitutes some of the key pathogens responsible for the global burden of diarrhoeal disease. With over 164 million reported cases per annum, shigellosis accounts for 1.1 million deaths...
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First detection and genetic characterization of porcine parvovirus 7 from Korean domestic pig farms

Ouh IO, Park S, Lee JY, Song JY, Cho IS, Kim HR, Park CK

Porcine parvovirus 7 (PPV7) was first detected in Korean pig farms in 2017. The detection rate of PPV7 DNA was 24.0% (30/125) in aborted pig fetuses and 74.9% (262/350) in...
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Unraveling Haplotype Diversity of the Apical Membrane Antigen-1 Gene in Plasmodium falciparum Populations in Thailand

Lumkul L, Sawaswong , Simpalipan P, Kaewthamasorn M, Harnyuttanakorn P, Pattaradilokrat S

Development of an effective vaccine is critically needed for the prevention of malaria. One of the key antigens for malaria vaccines is the apical membrane antigen 1 (AMA-1) of the...
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Structural analyses of putative porcine cluster of differentiation (CD) 24 gene

Ko H, Chai HH, Jang GW, Park JE, Kim JM, Lee KT

Cluster of differentiation (CD) 24 or heat stable antigen 24 (HSA) molecule is a mucin-type glycoprotein attached to the cell surface by glycosylphosphatidylinositol (GPI)-anchor, promoting adhesive interactions between cells or...
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Comprehensive Analysis of Non-Synonymous Natural Variants of G Protein-Coupled Receptors

Kim HR, Duc NM, Chung KY

G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane receptors and have vital signaling functions in various organs. Because of their critical roles in physiology and pathology, GPCRs are...
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Isolation and characterization of a new porcine epidemic diarrhea virus variant that occurred in Korea in 2014

Yang DK, Kim HH, Lee SH, Yoon SS, Park JW, Cho IS

Outbreaks of porcine epidemic diarrhea (PED) have resulted in significant economic losses in the swine industry, and another PED outbreak occurred in 2014 in Korea. Isolating and culturing PED virus...
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Prediction of Metal Ion Binding Sites in Proteins from Amino Acid Sequences by Using Simplified Amino Acid Alphabets and Random Forest Model

Kumar S

Metal binding proteins or metallo-proteins are important for the stability of the protein and also serve as co-factors in various functions like controlling metabolism, regulating signal transport, and metal homeostasis....
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Species Specific Antiviral Activity of Porcine Interferon-α8 (IFNα8)

Kim E, Jhun H, Kim J, Park U, Jo S, Kwak A, Kim S, Nguyen TT, Kang Y, Choi I, Lee J, Kim H, Kim Y, Lee S, Kim S

Interferons (IFNs) have been known as antiviral genes and they are classified by type 1, type 2, and type 3 IFN. The type 1 IFN consists of IFNα, IFNβ, IFNτ,...
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Sequence analysis of the spike gene of Porcine epidemic diarrhea virus isolated from South China during 2011–2015

Zhao X, Li Z, Zeng X, Zhang G, Niu J, Sun B, Ma J

The spike gene of porcine epidemic diarrhea virus (PEDV) was sequenced from 55 South China field strains isolated from pigs with symptoms of diarrhea. The sequences were compared within the...
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Characterization of a Biflaviolin Synthase CYP158A3 from Streptomyces avermitilis and Its Role in the Biosynthesis of Secondary Metabolites

Lim YR, Han S, Kim JH, Park HG, Lee GY, Le TK, Yun CH, Kim D

Streptomyces avermitilis produces clinically useful drugs such as avermectins and oligomycins. Its genome contains approximately 33 cytochrome P450 genes and they seem to play important roles in the biosynthesis of...
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Differences in Hematological and Clinical Features Between Essential Thrombocythemia Cases With JAK2- or CALR-Mutations

Kubuki Y, Shide K, Kameda T, Yamaji T, Sekine M, Kamiunten , Akizuki K, Shimoda H, Tahira Y, Nakamura K, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Hashimoto , Yamamoto S, Hasuike S, Hidaka T, Nagata K, Kitanaka A, Shimoda K

No abstract available.
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Identificaiton of Novel Immunogenic Human Papillomavirus Type 16 E7-Specific Epitopes Restricted to HLA-A*33;03 for Cervical Cancer Immunotherapy

Kim S, Chung HW, Kong HY, Lim JB

PURPOSE: To identify new immunogenic HLA-A*33;03-restricted epitopes from the human papillomavirus (HPV) 16 E7 protein for immunotherapy against cervical cancer. MATERIALS AND METHODS: We synthesized fourteen overlapping 15-amino acid peptides and...
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Complete Mitochondrial Genome of a Tongue Worm Armillifer agkistrodontis

Li J, He FN, Zheng HX, Zhang RX, Ren YJ, Hu W

Armillifer agkistrodontis (Ichthyostraca: Pantastomida) is a parasitic pathogen, only reported in China, which can cause a zoonotic disease, pentastomiasis. A complete mitochondrial (mt) genome was 16,521 bp comprising 13 protein-coding...
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Isolation and Genetic Characterization of Orientia tsutsugamushi from Scrub Typhus Patients in Gyeongsangnam-do, Korea

Ha JH, Lee DH, Park JS, Cho OH, Kim DH, Ha NY, Cho NH, Hwang KJ, Cho YG, Lee HS, Lee WK, Lee YC, Cho MJ, Lee WK, Shin MK

Orientia tsutsugamushi (O. tsutsugamushi), which is endemic to an Asia-Pacific region, has increased its incidence and caused annually around 10 thousand patients infected with scrub typhus in Korea in the...
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Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking

Sahoo M, Jena L, Rath SN, Kumar S

The influenza A (H1N1) virus, also known as swine flu is a leading cause of morbidity and mortality since 2009. There is a need to explore novel anti-viral drugs for...
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A Novel KIT INDEL Mutation in Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1

Lee JH, Park C, Kim SH, Shin MG

No abstract available.
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