- A role of Cyclosporine A that suppresses multi-drug resistance (MDR) in the secondary chemotherapy drug resistant cell line of ovarian cancer
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An CS, Kim SY, Park CM
- KMID: 2143513
- Korean J Gynecol Oncol.
- 2006 Dec;17(4):286-293.
OBJECTIVE: Resistant, recurrent ovarian cancer patients who had first chemotherapy with Cisplatin have showed low reactivity and high recurrence in the secondary chemotherapy. Therefore, multi-drug resistance (MDR) to chemotherapy is... -
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- Molecular Characteristics of blaOXA-23-Producing Acinetobacter baumannii Isolated from a University Hospital
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Jang IH, Park SD, Uh Y, Lee GS, Kim JB, Choi I
- KMID: 1494329
- Ann Clin Microbiol.
- 2013 Sep;16(3):126-133.
- doi: 10.5145/ACM.2013.16.3.126
BACKGROUND: Multi-drug resistant (MDR) Acinetobacter baumannii has emerged as a significant infectious agent in hospitals worldwide. The purpose of this study was to determine the molecular characterization of MDR A.... -
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- Change of MDR Gene Expression and Glutathione Metabolism during Long Standing Low-dose Cisplatin Exposure in Bladder Carcinoma Cell Line
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Lee ES, Kim SW, Yoon SJ, Lee HW, Ahn HJ, Lee CW
- KMID: 1663273
- Korean J Urol.
- 1996 Dec;37(12):1345-1350.
Resistance to anticancer chemotherapeutic drugs remains a major obstacle in cancer chemotherapy. A variety of mechanisms responsible for drug resistance has been posed. Mdr gene overexpression and detoxification by glutathione... -
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- Multidrug Resistance Mechanisms of Carbapenem Resistant Klebsiella pneumoniae Strains Isolated in Chongqing, China
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Yan J, Pu S, Jia X, Xu X, Yang S, Shi J, Sun S, Zhang L
- KMID: 2383915
- Ann Lab Med.
- 2017 Sep;37(5):398-407.
- doi: 10.3343/alm.2017.37.5.398
BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is considered a serious global threat. However, little is known regarding the multidrug resistance (MDR) mechanisms of CRKP. This study investigated the phenotypes and MDR... -
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- Relation among the Tests and Comparison of Positivity of Tests for Multi-Drug Resistance in Newly Diagnosed Acute Leukemia
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Lee NY, Bae HG, Kwon EH, Heo WB, Shin SH, Suh JS
- KMID: 2239566
- Korean J Lab Med.
- 2003 Jun;23(3):143-150.
BACKGROUND: The expression of multi-drug resistance (MDR) in acute leukemia was known to decrease the outcome of chemotherapy and to increase the rate of relapse. Of the mechanism of MDR,... -
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- Prognostic Significance of Multidrug Resistance Gene 1 (MDR1), Multidrug Resistance-related Protein (MRP) and Lung Resistance Protein (LRP) mRNA Expression in Acute Leukemia
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Huh HJ, Park CJ, Jang S, Seo EJ, Chi HS, Lee JH, Lee KH, Seo JJ, Moon HN, Ghim T
- KMID: 1781831
- J Korean Med Sci.
- 2006 Apr;21(2):253-258.
- doi: 10.3346/jkms.2006.21.2.253
The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression... -
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- Correlation of multidrug resistance gene expression with hestologic grade in locally advanced breast cancer
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Bae JW, Kim IS, Hwang JW
- KMID: 1694328
- J Korean Cancer Assoc.
- 1993 Jun;25(3):376-382.
No abstract available. -
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- The Effect of Medroxyprogesterone Acetate On Cytotoxicity of Vinblastine in Renal Cell Carcinoma Cell Lines
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Lee DH, Chung BH, Hong SJ
- KMID: 1914473
- Korean J Urol.
- 1997 Jan;38(1):1-6.
Inadequate effectiveness of anticancer drug in treating renal cell carcinoma has been attributed to the overexpression of multidrug resistance gene (MDR1) and its product, membrane-bound P-glycoprotein. P-glycoprotein is known to... -
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- A Study of Efflux Pump Genes in Mycobacterium tuberculosis Clinical Isolates
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Cho SY, Nam YS, Yang HS, Soh YS, Kim MJ, Lee HJ
- KMID: 1971096
- Ann Clin Microbiol.
- 2014 Jun;17(2):65-68.
- doi: 10.5145/ACM.2014.17.2.65
The efflux pump system has been suggested as an important mechanism in the drug resistance of Mycobacterium tuberculosis (MTB). In this study, molecular analysis of five genes in the efflux... -
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- The Cytotoxic and Radiosensitizing Effects of Taxol in Uterine Sarcoma Cell Lines
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Lee HY, Park DC, Kim SW, Lew YO, Kim DH
- KMID: 2272001
- Korean J Obstet Gynecol.
- 2003 Apr;46(4):725-731.
OBJECTIVE: The cytotoxic and radiosensitizing effects of Taxol in uterine sarcoma cell lines were investigated. METHODS: Two uterine sarcoma cell lines with different Taxol responses were used, namely, Taxol- sensitive and... -
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- Decoy Oligonucleotides on Which Nuclear Factor for YB-1 Bind Inhibit the Growth of Cancer Cells
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Han SW, Lee WS, Park CH, Kim HS, Choi SK, Rew JS, Lee SR, Li LH, Kim SJ, Chung SS, Shin BA
- KMID: 1514203
- Chonnam Med J.
- 2006 Aug;42(2):85-93.
Human YB-1 is a transcription factor binding on the inverted CCAAT box in the promoter region of various genes such as PCNA, DNA polymerase and MDR genes. We previously reported... -
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- Expression of Multidrug Resistance Genes, mdr1, mrp, Topo IIalpha and Topo IIbeta in Childhood Acute Lymphoblastic Leukemia
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Lim SH, Ko DH, Kook H, Yoon WS, Kim HJ, Kim SY, Kim CJ, Hwang TJ
- KMID: 2140617
- Korean J Pediatr Hematol Oncol.
- 2002 Apr;9(1):82-90.
PURPOSE: Multidrug resistance in the treatment of cancer mediated by several drug resistant genes impedes the successful management of cancer. The authors investigated the expression of drug resistant genes,... -
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- Distribution of adeG, adeB, adeE, adeY, abeM, and adeJ Efflux Pump Genes in Clinical Isolates of Acinetobacter Species from Korea
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Choi IS, Choi JA, Jang SJ, Park G, Jeong SH, Kim CM, Lee OJ, Kang SH, Moon DS
- KMID: 2458679
- Lab Med Online.
- 2019 Oct;9(4):201-209.
- doi: 10.3343/lmo.2019.9.4.201
BACKGROUND: The aim of the present study was to determine the frequency of six efflux pump genes in Acinetobacter clinical isolates collected from South Korean hospitals. METHODS: In this study, we... -
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- Expression of Multidrug Resistance Gene Product in Laryngeal Squamous Cell Carcinoma
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Chung SM
- KMID: 2052732
- Ewha Med J.
- 1996 Mar;19(1):125-131.
- doi: 10.12771/emj.1996.19.1.125
OBJECTIVES: Various mechanisms are involved in drug resistance of tumor cells. Among them one such mechanism is the overexpression of the multidrug resistance(mdr1) gene product P-glycoprotein(Pgp) that functions as an... -
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- Multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) gene expression in osteosarcoma and their prognostic significance
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Jung HG, Lee SH, Kim HS
- KMID: 2105711
- J Korean Orthop Assoc.
- 2001 Feb;36(1):1-8.
PURPOSE: The purpose of this study is to evaluate the correlations between the multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) gene in osteosarcoma, and their prognostic significances by RT-PCR... -
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- The Effect of Multidrug Resistance Modulators on Cytotoxicity of Adriamycin upon Human Renal Cell Carcinoma Cell Lines
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Kim HH, Ahn HJ, Song K, Lee ES, Lee CW
- KMID: 1913725
- Korean J Urol.
- 1994 Jan;35(1):1-12.
It is well known that renal cell carcinoma shows poor responses upon chemotherapy, and a multidrug-resistance has been suggested as one of the possible mechanisms of these resistances to chemotherapeutics... -
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- Analysis of MDR1(multidrug resistance) gene expression in bladder tumor and renal cell carcinoma by polymerase chain reaction
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Kim CS, Song KY, Kim KH
- KMID: 2114899
- Korean J Urol.
- 1992 Oct;33(5):771-777.
The expression of the multidrug resistance gene (MDR1, gene) is the main mechanism of tumor resistance to anticancer drugs. MDR1 gene encodes P-glycoprotein which functions as an efflux pump for... -
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- Expression of Glutathione-S-Transferase and P-glycoprotein in Human Cervical Cancer
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Byun TS, Bae SN, Kim YW, Chang BW, Kim DK, Kim SP
- KMID: 1855594
- Korean J Obstet Gynecol.
- 1998 Jan;41(1):10-16.
Expression of glutathione-S-transferase-pai and multidrug resistance gene was examined immunohistochemically in relation to the response to neoadjuvant chemotherapy with cisplatin and etoposide in 23 patients with primary squamous cell carcinoma... -
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- Multi-drug resistance (MDR1) gene expression in de novo acute leukemia cells: correlations with CD surface markers and treatment outcome
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Jiang EZ, Chang YJ, Lee JW, Lee WK, Kim JS, Sohn SK, Lee KB, Suh JS
- KMID: 1038442
- J Korean Med Sci.
- 1998 Dec;13(6):617-622.
- doi: 10.3346/jkms.1998.13.6.617
One important mechanism of drug resistance in acute leukemia is the overexpression of the multi-drug resistance (MDR1) gene that encodes a 170-kDa membrane protein called P-glycoprotein. To estimate the... -
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- Epileptogenic Properties of Balloon Cells in Cortical Tubers of Tuberous Sclerosis: Upregulation of Drug Resistance Proteins
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Kang NG, Chang HJ, Ok YC, Lee RS, Park SK, Lim JS, Cho KY, Kim HI, Kim JH, Oh HS, Lee MC
- KMID: 1956262
- J Korean Neurosurg Soc.
- 2007 Jun;41(6):397-402.
OBJECTIVES: Balloon cells and dysplastic neurons are histopathological hallmarks of the cortical tubers of tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) of the Taylor type. They are believed... -
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