Korean J Intern Med.  2001 Mar;16(1):24-29.

Clinical Significance of Anti-endothelial Cell Antibody in Renal Transplant Recipients

• Shin YS
• Yang CW
• Ahn HJ
• Park CW
• Jin DC
• Kim YS
• Chang YS
• Bang BK

Abstract

In order to evaluate the role of anti-endothelial cell antibody (AECA) in acute rejection in renal transplantation, serum AECA IgG titers were measured in 68 healthy controls, 111 chronic hemodialysis (HD) patients and 58 first renal transplant recipients. The AECA titer in hemodialysis patients was higher than in healthy controls (13.9+/-5.0 vs. 4.8+/-2.3 U/mL, p<0.01). In transplant recipients, AECA titers were not affected by dialysis mode (HD vs. CAPD vs. non-dialysis ; 9.6+/-7.6 vs. 7.9+/-3.9 vs. 11.9+/-3.1 U/mL, p>0.05). After renal transplantation, AECA titer was decreased significantly (vs. 4.7+/-3.6 U/mL, p<0.01). The serum AECA IgG titers increased significantly in recipients with acute rejection (6.9+/-3.1 vs. 13.5+/-9.9 U/mL, p<0.01), but decreased to 5.6+/-3.0 U/mL (p<0.01) after formal rejection therapy. In the recipients with acute rejection (n=27), the pre-renal transplant AECA titer was higher than in that without acute rejection (14.0+/-8.6 vs. 7.7+/-3.8 U/mL, p<0.01). The results of this study lead us to conclude that pre- and post-renal transplant AECA titer might be a useful predictor for acute rejection and useful for monitoring acute rejection in renal transplant recipients.

Keyword

Antiendothelial cell antibody; Kidney transplantation; Graft rejection; acute

MeSH Terms

Adult
Aged
Autoantibodies/analysis*
Biological Markers/analysis
Comparative Study
Enzyme-Linked Immunosorbent Assay
Female
Graft Rejection/immunology*
Human
Kidney Transplantation/immunology*
Kidney Transplantation/adverse effects
Male
Middle Age
Probability
Prognosis
Reference Values
Renal Dialysis
Sensitivity and Specificity
Statistics, Nonparametric
Transplantation Immunology/physiology