Korean J Intern Med.  1999 Jan;14(1):91-94.

Successful treatment with ganciclovir for cytomegalovirus duodenitis following allogenic bone marrow transplantation

• Ahn JH
• Lee JH
• Lee KH
• Kim WK
• Lee JS
• Bahng H
• Jung HY
• Kim YS
• Kim O
• Kim SH

Abstract

Cytomegalovirus(CMV) disease is a major cause of morbidity and mortality in immunocompromised patients. CMV enteritis should be considered when nausea and vomiting continue 3 to 4 weeks after bone marrow transplantation(BMT). The treatment of CMV enteritis is not well established. We report a CMV duodenitis patient following allogenic bone marrow transplantation. The patient had prolonged nausea and vomiting for 5 weeks after bone marrow transplantation and CMV duodenitis was diagnosed by the gastroduodenoscopic mucosal biopsy which showed cytomegalic cells. Ganciclovir treatment for 3 weeks resulted in the resolution of symptoms and promoted healing of the lesion. The patient was free of CMV infection until 288 days after allogenic BMT without maintenance ganciclovir treatment.

Keyword

Cytomegalovirus(CMV); BMT; Ganciclovir

MeSH Terms

Adult
Antiviral Agents/therapeutic use*
Bone Marrow Transplantation/adverse effects
Case Report
Cytomegalovirus Infections/etiology
Cytomegalovirus Infections/drug therapy*
Cytomegalovirus Infections/diagnosis
Duodenitis/etiology
Duodenitis/drug therapy*
Duodenitis/diagnosis
Ganciclovir/therapeutic use*
Human
Male
Transplantation, Homologous