Yonsei Med J.  2007 Jun;48(3):531-534. 10.3349/ymj.2007.48.3.531.

Disseminated Histoplasmosis and Tuberculosis in a Patient with HIV Infection

Affiliations
  • 1Division of Infectious Disease, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
  • 2Department of Pathology, Korea University College of Medicine, Seoul, Korea.
  • 3Division of Infectious Disease, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 4Department of Laboratory Medicine, Korea University College of Medicine, Seoul, Korea. eqcho1ku@korea.ac.kr

Abstract

Histoplasmosis is a very rare disease in Korea. Clinical manifestations are very similar to those of tuberculosis. This is the first case report of combined disseminated histoplasmosis and tuberculosis in a patient with HIV infection in Korea. A 42-year-old Korean with Acquired Immunodeficiency Syndrome (AIDS) was diagnosed with tuberculosis. He had lived in Guatemala for the past five years. Upon diagnosis of disseminated tuberculosis with HIV infection, he was treated with anti-tuberculosis medications and anti-retroviral agents. Fever, weakness, hepatosplenomegaly and pancytopenia were persistent despite treatment. The patient's history of living in Guatemala caused us to seek opportunistic infectious organisms other than tuberculosis. Bone marrow aspiration and biopsy were performed and the result revealed numerous intracellular organisms consistent with Histoplasma capsulatum; therefore, the diagnosis of disseminated histoplasmosis was made.


MeSH Terms

AIDS-Related Opportunistic Infections/microbiology
Acquired Immunodeficiency Syndrome/complications/pathology
Adult
Bone Marrow/microbiology/pathology
HIV Infections/*complications/drug therapy
Histoplasma/isolation & purification
Histoplasmosis/complications/*diagnosis/microbiology
Humans
Male
Thorax/microbiology/pathology/radionuclide imaging
Tuberculosis/complications/*diagnosis
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