Korean J Hematol.  2012 Mar;47(1):77-79. 10.5045/kjh.2012.47.1.77.

Histoplasmosis on bone marrow aspirate cytological examination associated with hemophagocytosis and pancytopenia in an AIDS patient

• Chandra H
• Chandra S
• Sharma A

• KMID: 2251975
• DOI: http://doi.org/10.5045/kjh.2012.47.1.77

Abstract

A 38-year-old woman who presented with unexplained fever and pancytopenia was subjected to a bone marrow examination. Her bone marrow aspirate smear showed no obvious pathological finding except for the presence of hemophagocytosis and mild plasmacytosis. In view of hemophagocytosis, a thorough examination of the smear was conducted and revealed the presence of histoplasmosis. She was advised to undergo evaluation of her immunological status, and she tested positive for human immunodeficiency virus (HIV) infection. This case highlights that hemophagocytosis in the marrow may be an early sign of underlying disease, and that careful examination of bone marrow smears may reveal subtle infections. In addition, histoplasmosis with hemophagocytosis may be associated with pancytopenia, and hence, the HIV status of the patient should always be investigated.

Keyword

Hemophagocytosis; Histoplasmosis; Bone marrow examination; Pancytopenia

MeSH Terms

Adult
Bone Marrow
Bone Marrow Examination
Female
Fever
Histoplasmosis
HIV
Humans
Pancytopenia

Figure

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  Fig. 1 Bone marrow aspirate showing hemophagocytosis (Jenner-Giemsa stain; 400×).

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  Fig. 2 Bone marrow aspirate showing yeast-like cells of histoplasmosis with a clear halo around them (Jenner-Giemsa stain; 400×).

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  Fig. 3 Bone marrow aspirate showing pseudohyphae budding from yeast-like cells (Gomori's methenamine silver stain; 400×).

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