Yonsei Med J.  2015 May;56(3):871-874. 10.3349/ymj.2015.56.3.871.

Chronic Cavitary Pulmonary Histoplasmosis in a Non-HIV and Immunocompromised Patient without Overseas Travel History

Affiliations
  • 1Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. cmcws@medimail.co.kr
  • 2Department of Pathology, Korea University College of Medicine, Seoul, Korea.

Abstract

Korea is not known as an endemic area for Histoplasma. However, we experienced a case of histoplasmosis in a person who had never been abroad. A 65-year-old female was admitted to the hospital for evaluation of multiple lung nodules. A computed tomography (CT) scan of the chest showed multiple ill-defined consolidations and cavitations in all lobes of both lungs. The patient underwent a CT-guided lung biopsy, and a histopathology study showed findings compatible with histoplasmosis. Based on biopsy results and clinical findings, the patient was diagnosed with chronic cavitary pulmonary histoplasmosis. The patient recovered completely following itraconazole treatment. This is the first case report of pulmonary histoplasmosis unconnected with either HIV infection or endemicity in Korea.

Keyword

Histoplasma capsulatum; immunocompromised host; Korea

MeSH Terms

Aged
Antifungal Agents/therapeutic use
Biopsy
Female
Histoplasma/*isolation & purification
Histoplasmosis/*diagnosis/drug therapy/microbiology
Humans
*Immunocompromised Host
Itraconazole/therapeutic use
Lung Diseases, Fungal/*diagnosis/drug therapy
Republic of Korea
Tomography, X-Ray Computed
Treatment Outcome
Antifungal Agents
Itraconazole
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