Dement Neurocogn Disord.
2022 Oct;21(4):126-137. 10.12779/dnd.2022.21.4.126.
Electroencephalography for Early Detection of Alzheimer’s Disease in Subjective Cognitive Decline
- Affiliations
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- 1Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea
- 2Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea
- 3Department of Neurology, Gachon University Gil Hospital, Incheon, Korea
- 4Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
- 5Department of Neurology, Inha University School of Medicine, Incheon, Korea
- 6Data Center for Korean EEG, College of Nursing, Seoul National University, Seoul, Korea
- 7iMediSync Inc., Seoul, Korea
- KMID: 2536276
- DOI: http://doi.org/10.12779/dnd.2022.21.4.126
Abstract
- Background and Purpose
Early detection of subjective cognitive decline (SCD) due to Alzheimer’s disease (AD) is important for clinical research and effective prevention and management. This study examined if quantitative electroencephalography (qEEG) could be used for early detection of AD in SCD.
Methods
Participants with SCD from 6 dementia clinics in Korea were enrolled. 18 F-florbetaben brain amyloid positron emission tomography (PET) was conducted for all the participants. qEEG was performed to measure power spectrum and source cortical activity.
Results
The present study included 95 participants aged over 65 years, including 26 amyloid PET (+) and 69 amyloid PET (−). In participants with amyloid PET (+), relative power at delta band was higher in frontal (p=0.025), parietal (p=0.005), and occipital (p=0.022) areas even after adjusting for age, sex, and education. Source activities of alpha 1 band were significantly decreased in the bilateral fusiform and inferior temporal areas, whereas those of delta band were increased in the bilateral cuneus, pericalcarine, lingual, lateral occipital, precuneus, posterior cingulate, and isthmus areas. There were increased connections between bilateral precuneus areas but decreased connections between left rostral middle frontal area and bilateral frontal poles at delta band in participants with amyloid PET (+) showed. At alpha 1 band, there were decreased connections between bilateral entorhinal areas after adjusting for covariates.
Conclusions
SCD participants with amyloid PET (+) showed increased delta and decreased alpha 1 activity. qEEG is a potential means for predicting amyloid pathology in SCD. Further longitudinal studies are needed to confirm these findings.
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