- HPV-18 E7 Interacts with Elk-1 Leading to Elevation of the Transcriptional Activity of Elk-1 in Cervical Cancer
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Go SH, Rho SB, Yang DW, Kim BR, Lee CH, Lee SH
- KMID: 2534710
- Biomol Ther.
- 2022 Nov;30(6):593-602.
- doi: 10.4062/biomolther.2022.108
The human papillomavirus (HPV)-18 E7 (E7) oncoprotein is a major transforming protein that is thought to be involved in the development of cervical cancer. It is well-known that E7 stimulates... -
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- Study Design and Baseline Results in a Cohort Study to Identify Predictors for the Clinical Progression to Mild Cognitive Impairment or Dementia From Subjective Cognitive Decline (CoSCo) Study
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Ho S, Hong YJ, Jeong JH, Park KH, Kim S, Wang MJ, Choi SH, Han S, Yang DW
- KMID: 2536278
- Dement Neurocogn Disord.
- 2022 Oct;21(4):147-161.
- doi: 10.12779/dnd.2022.21.4.147
Background and Purpose: Subjective cognitive decline (SCD) refers to the self-perception of cognitive decline with normal performance on objective neuropsychological tests. SCD, which is the first help-seeking stage and the... -
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- Electroencephalography for Early Detection of Alzheimer’s Disease in Subjective Cognitive Decline
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Shim Y, Yang DW, Ho S, Hong YJ, Jeong JH, Park KH, Kim S, Wang MJ, Choi SH, Kang SW
- KMID: 2536276
- Dement Neurocogn Disord.
- 2022 Oct;21(4):126-137.
- doi: 10.12779/dnd.2022.21.4.126
Background and Purpose: Early detection of subjective cognitive decline (SCD) due to Alzheimer’s disease (AD) is important for clinical research and effective prevention and management. This study examined if quantitative... -
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- A Multinational, Multicenter, Randomized, Double-Blind, Active Comparator, Phase III Clinical Trial to Evaluate the Efficacy and Safety of Donepezil Transdermal Patch in Patients With Alzheimer’s Disease
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Han HJ, Park MY, Park KW, Park KH, Choi SH, Kim HJ, Yang DW, Ebenezer EGAM, Yang YH, Kewalram GM, Han SH, oBtI3S
- KMID: 2530857
- J Clin Neurol.
- 2022 Jul;18(4):428-436.
- doi: 10.3988/jcn.2022.18.4.428
Background and Purpose Oral administration of cholinesterase inhibitors is often associated with adverse gastrointestinal effects, and so developing an alternative administration route, such as transdermal, is urgently needed. The primary... -
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- Polymorphisms in TYMS for Prediction of Capecitabine-Induced Hand-Foot Syndrome in Chinese Patients with Colorectal Cancer
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Dong SQ, Wang TM, Zhang JB, He YQ, Xue WQ, Wu ZY, Yang DW, Cao LJ, Huang JW, Li XZ, Zhang PF, Zheng XH, Jia WH
- KMID: 2518396
- Cancer Res Treat.
- 2021 Jul;53(3):724-732.
- doi: 10.4143/crt.2020.457
Purpose Capecitabine is an extensively used oral prodrug of 5-fluorouracil in treatment of colon cancer and is known to cause hand-foot syndrome (HFS). As the target enzyme for capecitabine, thymidylate... -
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- Direct reprogramming of fibroblasts into diverse lineage cells by DNA demethylation followed by differentiating cultures
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Yang DW, Moon J, Ko HM, Shin YK, Fukumoto S, Kim SH, Kim MS
- KMID: 2507729
- Korean J Physiol Pharmacol.
- 2020 Nov;24(6):463-472.
- doi: 10.4196/kjpp.2020.24.6.463
Direct reprogramming, also known as a trans-differentiation, is a technique to allow mature cells to be converted into other types of cells without inducing a pluripotent stage. It has been... -
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- Coping with Dementia in the Middle of the COVID-19 Pandemic
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Ryoo Ny, Pyun JM, Baek MJ, Suh Jw, Kang MJ, Wang MJ, Youn YC, Yang DW, Kim SY, Park YH, Kim SY
- KMID: 2508433
- J Korean Med Sci.
- 2020 Nov;35(42):e383.
- doi: 10.3346/jkms.2020.35.e383
Multiple neurological complications have been associated with the coronavirus disease-19 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2. This is a narrative review to gather information on... -
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- The health-related quality-of-life of chronic obstructive pulmonary disease patients and disease-related indirect burdens
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Choi HS, Yang DW, Rhee CK, Yoon HK, Lee JH, Lim SY, Kim YI, Yoo KH, Hwang YI, Lee SH, Park YB
- KMID: 2505603
- Korean J Intern Med.
- 2020 Sep;35(5):1136-1144.
- doi: 10.3904/kjim.2018.398
Background/Aims: Many chronic obstructive pulmonary disease (COPD) patients have physical limitations. We investigated EuroQol five-dimensions five-level (EQ-5D-5L) of COPD patients to assess quality of life, and assessed indirect burden including time... -
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- Reliability and Validity of a Short Form of the Korean Dementia Screening Questionnaire-Cognition
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Kim A, Kim S, Park KW, Park KH, Youn YC, Lee DW, Lee JY, Lee JH, Jeong JH, Choi SH, Han HJ, Kim S, Na S, Park M, Yim HW, Yang DW
- KMID: 2467797
- J Clin Neurol.
- 2020 Jan;16(1):145-153.
- doi: 10.3988/jcn.2020.16.1.145
BACKGROUND AND PURPOSE: We aimed to determine the reliability and validity of a short form of the Korean Dementia Screening Questionnaire-Cognition (KDSQ-C) as a screening tool for cognitive dysfunction. METHODS: This... -
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- Coexistence of Cerebral Microbleeds and Amyloid Pathology in Patients with Cognitive Complaints
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Lim EY, Ryu SY, Shim YS, Yang DW, Cho AH
- KMID: 2467788
- J Clin Neurol.
- 2020 Jan;16(1):83-89.
- doi: 10.3988/jcn.2020.16.1.83
BACKGROUND AND PURPOSE: We investigated the prevalence of amyloid positivity and cerebral microbleeds (CMBs) in subjects with cognitive complaints with the aim of identifying differences in clinical parameters and cognitive... -
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- Different Cortical Thinning Patterns Depending on Their Prognosis in Individuals with Subjective Cognitive Decline
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Lim EY, Shim YS, Hong YJ, Ryu SY, Cho AH, Yang DW
- KMID: 2466754
- Dement Neurocogn Disord.
- 2019 Dec;18(4):113-121.
- doi: 10.12779/dnd.2019.18.4.113
BACKGROUND AND PURPOSE: Subjective cognitive decline (SCD) may be the first stage corresponding to subtle cognitive changes in patients with Alzheimer's disease (AD) spectrum disorders. We evaluated the differences in... -
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- A Comparative Evaluation of the KDSQ-C, AD8, and SMCQ as a Cognitive Screening Test to Be Used in National Medical Check-ups in Korea
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Kim A, Kim S, Park KW, Park KH, Youn YC, Lee DW, Lee JY, Lee JH, Jeong JH, Choi SH, Han HJ, Kim S, Na S, Park M, Yim HW, Yang DW
- KMID: 2442646
- J Korean Med Sci.
- 2019 Apr;34(14):e111.
- doi: 10.3346/jkms.2019.34.e111
BACKGROUND: Korea has a periodic general health check-up program that uses the Korean Dementia Screening Questionnaire-Cognition (KDSQ-C) as a cognitive dysfunction screening tool. The Alzheimer Disease 8 (AD8) and Subjective... -
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- Direct and Indirect Costs of Chronic Obstructive Pulmonary Disease in Korea
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Kim C, Kim Y, Yang DW, Rhee CK, Kim SK, Hwang YI, Park YB, Lee YM, Jin S, Park J, Hahm CR, Park CH, Park SY, Jung CK, Kim YI, Lee SH, Yoon HK, Lee JH, Lim SY, Yoo KH
- KMID: 2441727
- Tuberc Respir Dis.
- 2019 Jan;82(1):27-34.
- doi: 10.4046/trd.2018.0035
BACKGROUND: Understanding the burden of disease is important to establish cost-effective treatment strategies and to allocate healthcare resources appropriately. However, little reliable information is available regarding the overall economic burden... -
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- Age-Specific Cutoff Scores on a T1-Weighted Axial Medial Temporal-Lobe Atrophy Visual Rating Scale in Alzheimer's Disease Using Clinical Research Center for Dementia of South Korea Data
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Choi GS, Kim GH, Choi JH, Hwang J, Kwon E, Lee SA, Kong KA, Kang HJ, Yoon B, Kim BC, Yang DW, Na DL, Kim EJ, Na HR, Han HJ, Lee JH, Kim JH, Lee KY, Park KH, Park KW, Kim S, Han SH, Kim SY, Yoon SJ, Moon SY, Youn YC, Choi SH, Jeong JH
- KMID: 2415041
- J Clin Neurol.
- 2018 Jul;14(3):275-282.
- doi: 10.3988/jcn.2018.14.3.275
BACKGROUND AND PURPOSE: Visual assessment of medial temporal-lobe atrophy (MTA) has been quick, reliable, and easy to apply in routine clinical practice. However, one of the limitations in visual assessments... -
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- Safety and Efficacy of Anti-dementia Agents in the Extremely Elderly Patients with Dementia
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Lim EY, Yang DW, Kim JS, Cho AH
- KMID: 2410525
- J Korean Med Sci.
- 2018 May;33(19):e133.
- doi: 10.3346/jkms.2018.33.e133
BACKGROUND: There are debates on representation and generalizability of previous randomized controlled trials about anti-dementia agents in the oldest old population. In this context, we aimed to investigate the efficacy... -
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- Clinical Predictors for Mild Cognitive Impairment Progression in a Korean Cohort
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Shim YS, Yang DW, Yoon B, Lee Y, Hong CH, Seo SW, Yoon SJ, Jeong JH, Park MH, Choi SH, Kim SY
- KMID: 2442848
- Dement Neurocogn Disord.
- 2016 Sep;15(3):68-74.
- doi: 10.12779/dnd.2016.15.3.68
BACKGROUND AND PURPOSE: Patients with mild cognitive impairment (MCI) and their caregivers are concerned with the likelihood and time course of progression to dementia. This study was performed to identify... -
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- Reduced Gray Matter Volume in Subjective Cognitive Decline: A Voxel-Based Morphometric Study
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Choi Y, Yoon BN, Choi SH, Lim MK, Kim HJ, Yang DW
- KMID: 2442931
- Dement Neurocogn Disord.
- 2015 Dec;14(4):143-148.
- doi: 10.12779/dnd.2015.14.4.143
BACKGROUND AND PURPOSE: Subjective cognitive decline has been proposed as a potential indicator of the preclinical state of Alzheimer's disease (AD). The results of the studies of cortical atrophy on... -
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- Gray and White Matter Degenerations in Subjective Memory Impairment: Comparisons with Normal Controls and Mild Cognitive Impairment
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Hong YJ, Yoon B, Shim YS, Ahn KJ, Yang DW, Lee JH
- KMID: 2351117
- J Korean Med Sci.
- 2015 Nov;30(11):1652-1658.
- doi: 10.3346/jkms.2015.30.11.1652
Subjective memory impairment (SMI) is now increasingly recognized as a risk factor of progression to dementia. This study investigated gray and white matter changes in the brains of SMI patients... -
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- Blood Pressure and Heart Rate Variability in Alzheimer's Disease
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Kim JS, Park HE, Oh YS, An JY, Park SK, Han SR, Park JW, Yang DW, Shim YS, Lee KS
- KMID: 2442989
- Dement Neurocogn Disord.
- 2015 Sep;14(3):128-134.
- doi: 10.12779/dnd.2015.14.3.128
BACKGROUND AND PURPOSE: Altered blood pressure (BP) and heart rate variations (HRVs) have been reported in Alzheimer's disease (AD). However, it is unclear how these two manifestations are associated with... -
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- The Effects of Occupational Therapy and Music Therapy on Patients With Mild Cognitive Impairment: A Pilot Study
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Lim EY, Yang DW, Shim YS, Yoon B, Hong YJ, Moon MS
- KMID: 1879405
- J Korean Geriatr Soc.
- 2015 Jun;19(2):71-79.
- doi: 10.4235/jkgs.2015.19.2.71
BACKGROUND: Patients with mild cognitive impairment (MCI) are at an increased risk for developing dementia, especially Alzheimer disease; and pharmacological therapy for MCI is limited. As a result, nonpharmacological mediums... -
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