Korean J Pancreas Biliary Tract.  2022 Jul;27(3):121-127. 10.15279/kpba.2022.27.3.121.

Multi-Center Study on Gender Difference in Resectability and Pathologic Prognosis of Gallbladder Cancer

• Park YT
• Kang J
• Kim JS
• Jung MK
• Kim SH
• Cho JH
• Woo SM
• Lee KJ
• Kim EJ
• Kim HJ

• KMID: 2532498
• DOI: http://doi.org/10.15279/kpba.2022.27.3.121

Abstract

Background
/Aim: In gallbladder cancer (GBC), gender differences in incidence and mortality rates have been reported with geographic variation. However, there is little known about sex-related difference in GBC prognosis. This study compares prognostic factors according to gender for GBC.
Methods
We searched clinicopathological factors in all stages of 952 GBC patients from seven medical centers in Korea. A total of 927 patients were enrolled and surgery with curative resection was performed in 499 patients.
Results
Carbohydrate antigen (≥37 U/mL) was a significant prognostic factor in both females and males (odd ratio [OR], 4.30; 95% confidence interval [CI], 3.13-5.89; p<0.001). Age was a significant factor only in female patients, elderly patients were associated with low resectability and the likelihood of T-stage >2; an independent predictor of poor prognosis via multivariate analysis (OR, 1.03; 95% CI, 1.01-1.05; p=0.005, OR, 1.05; 95% CI, 1.02-1.08; p=0.002). Body mass index (BMI) also showed gender difference, and lower BMI (≤25 kg/m²) was the significant good indicator of multivariate analysis for lymph node metastasis in female patients (OR, 0.42; 95% CI, 0.23-0.77; p=0.005) but, the significant poor indicator of univariate analysis for advanced T-stage in male (OR, 2.79; 95% CI, 1.40-5.54; p=0.003).
Conclusions
These results suggest that there is a possibility of gender difference in GBC prognosis. Age and high BMI were poor prognostic factors for curative resection for female GBC patients.

Keyword

성차; 나이; 체질량지수; CA 19-9; 빌리루빈; Gender; Age factors; Body mass index; CA-19-9 antigen; Bilirubin