Ann Geriatr Med Res.
2022 Jun;26(2):72-82. 10.4235/agmr.22.0036.
Importance of Sclerostin as Bone-Muscle Mediator Crosstalk
- Affiliations
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- 1Division of Geriatric Medicine, Department of Internal Medicine, Sanglah Hospital–Faculty of Medicine Udayana University, Bali, Indonesia
- 2Department of Internal Medicine, North Lombok Regional Hospital, West Nusa Tenggara, Indonesia
- 3Division of Geriatric Medicine, Department of Internal Medicine, Cipto Mangunkusumo Hospital–Faculty of Medicine University of Indonesia, Jakarta, Indonesia
- KMID: 2531899
- DOI: http://doi.org/10.4235/agmr.22.0036
Abstract
- Loss of bone and muscle mass is a frequent aging condition and has become a growing public health problem. The term “osteosarcopenia” denotes close links between bone and muscle. Mechanical exercise was once thought to be the only mechanism of crosstalk between muscle and bone. Sclerostin is an important player in the process of unloading-induced bone loss and plays an important role in mechanotransduction in the bone. Furthermore, bones and muscles are categorized as endocrine organs because they produce hormone-like substances, resulting in “bone-muscle crosstalk.” Sclerostin, an inhibitor of bone development, has recently been shown to play a role in myogenesis. This review discusses the importance of sclerostin in bone-muscle crosstalk.
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