J Korean Assoc Oral Maxillofac Surg.  2018 Dec;44(6):289-292. 10.5125/jkaoms.2018.44.6.289.

Gingival crevicular fluid levels of sclerostin in chronic periodontitis and healthy subjects

• Rezaei Esfahrood Z
• Yadegari Z
• Veysari SK
• Kadkhodazadeh M

• KMID: 2467176
• DOI: http://doi.org/10.5125/jkaoms.2018.44.6.289

Abstract

OBJECTIVES
Chronic periodontitis is a common inflammatory disease of the oral cavity that causes destruction of periodontal tissues and bone around the teeth. Sclerostin is a protein encoded by the SOST gene. In this study, gingival crevicular fluid (GCF) levels of sclerostin in patients with chronic periodontitis were compared with those of healthy subjects.
MATERIALS AND METHODS
In this case-control study, a total of 40 subjects were enrolled and divided into the healthy group (n=23) and chronic periodontitis group (n=17). GCF samples were collected, and the concentration of sclerostin was evaluated using enzyme-linked immunosorbent assay. Comparison of significance between groups was assessed using Mann-Whitney U test.
RESULTS
Sclerostin concentration was significantly higher in the chronic periodontitis group compared with the healthy group (P < 0.005).
CONCLUSION
Despite the limitations of this study, sclerostin can be a possible marker for assessment of periodontal health status.

Keyword

Sclerostin; Periodontitis; Gingival crevicular fluid

MeSH Terms

Case-Control Studies
Chronic Periodontitis*
Enzyme-Linked Immunosorbent Assay
Gingival Crevicular Fluid*
Healthy Volunteers*
Humans
Mouth
Periodontitis
Tooth