Arch Hand Microsurg.  2021 Sep;26(3):161-165. 10.12790/ahm.21.0096.

Management of a Huge Tenosynovial Giant Cell Tumor of the Wrist

Affiliations
  • 1Department of Orthopaedic Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
  • 2Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
  • 3Department of Orthopaedic Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
  • 4Department of Orthopaedic Surgery, Soonchunhyang University Seoul Hospital, Seoul, Korea

Abstract

Tenosynovial giant cell tumors (TGCTs) are typically benign neoplasms of the joint, bursa, and tendon sheath. Usually, TGCT presents as a small localized tumor on the hand and wrist. The diffuse-type TGCT is more aggressive and mainly affects large joints such as knees, hips, ankles, and elbows. Diffuse-type TGCT of small joints is rare. To our knowledge, this is a very rare case of a huge diffuse-type TGCT on the wrist. We report a huge TGCT, which grew gradually over 10 years.

Keyword

Tenosynovial; Giant cell tumors; Tumor

Figure

  • Fig. 1. (A) A magnetic resonance imaging scan showed an extensive multi-lobulated soft tissue mass in the volar aspect of the patient's wrist, arising from the flexor tendons. (B) A magnetic resonance imaging scan showed an extensive multi-lobulated soft tissue mass in the volar aspect of his hand, arising from the flexor tendons.

  • Fig. 2. (A) Mass located only on the surface of the flexor tendons. It had partially infiltrated the tendons. (B) The mass consisting of multiple pieces of dark-brown soft tissue with soft consistency measuring 60 × 30 × 18 mm was removed.

  • Fig. 3. Histological examination of the tumor using H&E stain (×200). The mass is characterized by sheets of multinucleated giant cells in the background of the mononuclear cell.


Reference

1. Lu H, Shen H, Chen Q, Shen XQ, Wu SC. Artificial finger joint replacement due to a giant cell tumor of the tendon sheath with bone destruction: a case report. Oncol Lett. 2015; 10:3502–4.
Article
2. Zambo I, Veselý K. WHO klasifikace nádorů měkkých tkání a kostí 2013: hlavní změny oproti 3. vydání [WHO classification of tumours of soft tissue and bone 2013: the main changes compared to the 3rd edition]. Cesk Patol. 2014; 50:64–70. Czech.
3. Zhao Q, Lu H. Giant cell tumor of tendon sheath in the wrist that damaged the extensor indicis proprius tendon: a case report and literature review. BMC Cancer. 2019; 19:1057.
Article
4. Sansone V, Longhino V. What's in a name? A call for consistency in the classification of tenosynovial giant cell tumour. Knee. 2018; 25:1322–3.
Article
5. Gouin F, Noailles T. Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). Orthop Traumatol Surg Res. 2017; 103:S91–7.
Article
6. Hoch BL, Garcia RA, Smalberger GJ. Chondroid tenosynovial giant cell tumor: a clinicopathological and immunohistochemical analysis of 5 new cases. Int J Surg Pathol. 2011; 19:180–7.
Article
7. Rockberg J, Bach BA, Amelio J, et al. Incidence trends in the diagnosis of giant cell tumor of bone in Sweden since 1958. J Bone Joint Surg Am. 2015; 97:1756–66.
Article
8. Fraser EJ, Sullivan M, Maclean F, Nesbitt A. Tenosynovial giant-cell tumors of the foot and ankle: a critical analysis review. JBJS Rev. 2017; 5:01874474-201701000-00001.
Article
9. Mastboom MJ, Palmerini E, Verspoor FGM, et al. Surgical outcomes of patients with diffuse-type tenosynovial giant-cell tumours: an international, retrospective, cohort study. Lancet Oncol. 2019; 20:877–86.
10. Murphey MD, Rhee JH, Lewis RB, Fanburg-Smith JC, Flemming DJ, Walker EA. Pigmented villonodular synovitis: radiologic-pathologic correlation. Radiographics. 2008; 28:1493–518.
Article
11. West RB, Rubin BP, Miller MA, et al. A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. Proc Natl Acad Sci U S A. 2006; 103:690–5.
Article
12. Staals EL, Ferrari S, Donati DM, Palmerini E. Diffuse-type tenosynovial giant cell tumour: current treatment concepts and future perspectives. Eur J Cancer. 2016; 63:34–40.
Article
13. Kan JH, Hernanz-Schulman M, Damon BM, Yu C, Connolly SA. MRI features of three paediatric intra-articular synovial lesions: a comparative study. Clin Radiol. 2008; 63:805–12.
Article
14. Chen EL, de Castro CM 4th, Hendzel KD, et al. Histologically benign metastasizing tenosynovial giant cell tumor mimicking metastatic malignancy: a case report and review of literature. Radiol Case Rep. 2019; 14:934–40.
Article
15. Roeder F, Timke C, Zwicker F, et al. Intensity modulated radiotherapy (IMRT) in benign giant cell tumors--a single institution case series and a short review of the literature. Radiat Oncol. 2010; 5:18.
Article
16. Healey JH, Bernthal NM, van de Sande M. Management of tenosynovial giant cell tumor: a neoplastic and inflammatory disease. J Am Acad Orthop Surg Glob Res Rev. 2020; 4:e20.00028.
Article
17. Mollon B, Lee A, Busse JW, et al. The effect of surgical synovectomy and radiotherapy on the rate of recurrence of pigmented villonodular synovitis of the knee: an individual patient meta-analysis. Bone Joint J. 2015; 97-B:550–7.
18. Horoschak M, Tran PT, Bachireddy P, et al. External beam radiation therapy enhances local control in pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys. 2009; 75:183–7.
Article
19. Stephan SR, Shallop B, Lackman R, Kim TW, Mulcahey MK. Pigmented villonodular synovitis: a comprehensive review and proposed treatment algorithm. JBJS Rev. 2016; 4:01874474-201607000-00005.
20. Tap WD, Wainberg ZA, Anthony SP, et al. Structure-guided blockade of CSF1R kinase in tenosynovial giant-cell tumor. N Engl J Med. 2015; 373:428–37.
Article
21. Palmerini E, Staals EL, Maki RG, et al. Tenosynovial giant cell tumour/pigmented villonodular synovitis: outcome of 294 patients before the era of kinase inhibitors. Eur J Cancer. 2015; 51:210–7.
Article
Full Text Links
  • AHM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr