J Rheum Dis.  2021 Apr;28(2):107-109. 10.4078/jrd.2021.28.2.107.

Trisomy 8 Associated Behçet’s Like Disease

• Lee S
• Choi WH
• Kim JS
• Lee KA
• Jeon SR
• Kim HS

• KMID: 2514122
• DOI: http://doi.org/10.4078/jrd.2021.28.2.107

Figure

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  Figure 1 (A) Computed tomography finding showed layered enhancing wall thickening with perilesional fat infilteration and ulceration in terminal ileum. (B) Colonoscopic finding revealed large well defined deep oval ulcers in ileocecal valve.

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  Figure 2 Perianal fistula was observed and seton tube drainage was performed.

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  Figure 3 Karyotyping of this patient revealed trisomy 8 (arrow).

Reference

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2. Ahn JK, Cha HS, Koh EM, Kim SH, Kim YG, Lee CK, et al. 2008; Behcet's disease associated with bone marrow failure in Korean patients: clinical characteristics and the association of intestinal ulceration and trisomy 8. Rheumatology (Oxford). 47:1228–30. DOI: 10.1093/rheumatology/ken162. PMID: 18550640.

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4. Toyonaga T, Nakase H, Matsuura M, Minami N, Yamada S, Honzawa Y, et al. 2013; Refractoriness of intestinal Behçet's disease with myelodysplastic syndrome involving trisomy 8 to medical therapies - our case experience and review of the literature. Digestion. 88:217–21. DOI: 10.1159/000355341. PMID: 24247154.

5. Asano T, Sato S, Furuya MY, Takahashi H, Shichishima-Nakamura A, Ohkawara H, et al. 2019; Intestinal Behçet disease associated with myelodysplastic syndrome accompanying trisomy 8 successfully treated with abdominal surgery followed by hematopoietic stem cell transplantation: a case report. Medicine (Baltimore). 98:e17979. DOI: 10.1097/MD.0000000000017979. PMID: 31725663. PMCID: PMC6867715.