Korean J Transplant.  2020 Dec;34(Supple 1):S129. 10.4285/ATW2020.OP-1131.

Study on patients without underlying chronic liver disease to improve survival outcome in pediatric liver transplantation

Affiliations
  • 1Department of Surgery, Seoul National University Hospital, Seoul, Korea

Abstract

Background
Although liver transplantation (LT) is currently the standard treatment for pediatric end-stage liver disease (PELD), it remains associated with significant complications. This study aimed to identify risk factors affecting the outcomes of pediatric LT.
Methods
Data from pediatric patients who underwent primary LT from March 1988 to December 2018 were retrospectively analyzed. Chronic liver disease was defined as an explanted liver showing fibrosis regardless of grade, cirrhosis, or any other underlying disease that may cause progressive liver injury leading to fibrosis or cirrhosis.
Results
A total of 255 pediatric patients underwent LT during the study period. Their 1-, 5-, and 10-year overall survival rates were 90.5%, 88.4%, and 87.8%, respectively, while the 1-, 5-, and 10-year graft survival rates were 89.7%, 88.5%, and 87.2%, respectively. Multivariate analysis showed that liver disease without underlying chronic liver disease (P=0.024) and PELD score ≥30 (P=0.036) were associated with worse survival. Furthermore, bodyweight <6 kg (P=0.050), whole-liver deceased donor LT compared to living donor LT (P=0.008), fulminant liver failure (P=0.008), and postoperative hepatic artery complications (P<0.001) were risk factors for graft survival. Liver disease without underlying chronic liver disease was the only factor independently associated with hepatic artery complications (P=0.003).
Conclusions
Greater caution is recommended in pediatric patients with liver disease unaccompanied by underlying chronic liver disease, high PELD score, or low body weight to improve survival after LT. Hepatic artery complications were the only surgical complications affecting graft survival, especially in patients with liver disease but no underlying chronic liver disease.

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