Ultrasonography.  2020 Jul;39(3):288-297. 10.14366/usg.19090.

Comparison of point and 2-dimensional shear wave elastography for the evaluation of liver fibrosis

Affiliations
  • 1Department of Radiology, Hallym University Sacred Heart Hospital, Anyang, Korea
  • 2Department of Radiology, Seoul National University Hospital, Seoul, Korea
  • 3Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
  • 4Department of Pathology, Hallym University Sacred Heart Hospital, Anyang, Korea
  • 5Department of Surgery, Hallym University Sacred Heart Hospital, Anyang, Korea
  • 6Department of Statistics and Institute of Statistics, Hallym University, Chuncheon, Korea

Abstract

Purpose
This study aimed to assess the technical performance of ElastQ Imaging compared with ElastPQ and to investigate the correlation between liver stiffness (LS) values obtained using these two techniques.
Methods
This retrospective study included 249 patients who underwent LS measurements using both ElastPQ and ElastQ Imaging equipped on the same machine. The applicability, repeatability (coefficient of variation [CV]), acquisition time, and LS values were compared using the chi-square or Wilcoxon signed-rank tests. In the development group, the correlation between the LS values obtained by the two techniques was assessed with Spearman correlation coefficients and linear regression analysis. In the validation group, the agreement between the estimated and real LS values was evaluated using a Bland-Altman plot.
Results
ElastQ Imaging had higher applicability (94.0% vs. 78.3%, P<0.001) and higher repeatability, with a lower median CV (0.127 vs. 0.164, P<0.001) than did ElastPQ. The median acquisition time of ElastQ Imaging was significantly shorter than that of ElastPQ (45.5 seconds vs. 96.5 seconds, P<0.001). The median LS value obtained using ElastQ Imaging was significantly higher than that obtained using ElastPQ (5.60 kPa vs. 5.23 kPa, P<0.001). The LS values between the two techniques exhibited a strong positive correlation (r=0.851, P<0.001) in the development group. The mean difference and 95% limits of agreement were 0.0 kPa (-3.9 to 3.9 kPa) in the validation group.
Conclusion
ElastQ Imaging may be more reliable and faster than ElastPQ, with strongly correlated LS measurements.

Keyword

Liver fibrosis; Ultrasonography; Elastography; ARFI Imaging
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