- Liver fibrosis in children: a comprehensive review of mechanisms, diagnosis, and therapy
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Ozdogan E, Arikan C
- KMID: 2539776
- Clin Exp Pediatr.
- 2023 Mar;66(3):110-124.
- doi: 10.3345/cep.2022.00367
Chronic liver disease incidence is increasing among children worldwide due to a multitude of epidemiological changes. Most of these chronic insults to the pediatric liver progress to fibrosis and cirrhosis... -
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- Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future
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Yu JH, Lee HA, Kim SU
- KMID: 2539796
- Clin Mol Hepatol.
- 2023 Feb;29(Suppl):S136-S149.
- doi: 10.3350/cmh.2022.0436
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide and becoming a major cause of liver disease-related morbidity and mortality. The presence of liver fibrosis in patients with NAFLD is... -
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- Identification of high-risk subjects in nonalcoholic fatty liver disease
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Stern C, Castera L
- KMID: 2539801
- Clin Mol Hepatol.
- 2023 Feb;29(Suppl):S196-S206.
- doi: 10.3350/cmh.2022.0431
Non-alcoholic fatty liver disease (NAFLD) is becoming the most common liver disease worldwide, and its burden is expected to increase due to the growing epidemic of obesity and diabetes. The... -
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- Noninvasive serum biomarkers for liver fibrosis in NAFLD: current and future
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Reinson T, Buchanan RM, Byrne CD
- KMID: 2539798
- Clin Mol Hepatol.
- 2023 Feb;29(Suppl):S157-S170.
- doi: 10.3350/cmh.2022.0348
In the last 20 years, noninvasive serum biomarkers to identify liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) have been developed, validated against liver biopsy (the gold standard... -
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- Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis
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Song W, Yoo , Jang J, Baik SJ, Lee BK, Lee HW, Park JS
- KMID: 2538164
- Gut Liver.
- 2023 Jan;17(1):130-138.
- doi: 10.5009/gnl220041
Background/Aims: There are no data regarding the association between sarcopenic obesity status and nonalcoholic fatty liver disease (NAFLD) and NAFLD-associated liver fibrosis. Therefore, we aimed to investigate the relationship between... -
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- Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis
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Lee KC, Wu PS, Lin HC
- KMID: 2538202
- Clin Mol Hepatol.
- 2023 Jan;29(1):77-98.
- doi: 10.3350/cmh.2022.0237
The initial presentation of non-alcoholic steatohepatitis (NASH) is hepatic steatosis. The dysfunction of lipid metabolism within hepatocytes caused by genetic factors, diet, and insulin resistance causes lipid accumulation. Lipotoxicity, oxidative... -
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- Succinate Induces Liver Damage and Hepatic Fibrosis in a Mouse Model
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Le CT, Nguyen G, Dong HN, Park SY, Cho YK, Choi DH, Park WS, Lee Y, Lee JY, Cho EH
- KMID: 2536901
- Keimyung Med J.
- 2022 Dec;41(2):84-91.
- doi: 10.46308/kmj.2022.00143
Hepatic stellate cells (HSCs) play a key role in liver fibrosis. Succinate and succinate receptor (GPR91) signaling pathway are involved in the activation, proliferation, and migration of HSCs. We investigated... -
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- Accuracy of Noninvasive Scoring Systems in Assessing Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
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Han S, Choi M, Lee B, Lee HW, Kang SH, Cho Y, Ahn SB, Song 8 DS, Jun DW, Lee J, Yoo JJ
- KMID: 2535198
- Gut Liver.
- 2022 Nov;16(6):952-963.
- doi: 10.5009/gnl210391
Background/Aims: Several noninvasive scoring systems have been developed to determine the risk of advanced fibrosis in nonalcoholic fatty liver disease (NAFLD). We examined the diagnostic accuracy of the fibrosis-4 (FIB-4)... -
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- Peri-Operative Liver Fibrosis and Native Liver Survival in Pediatric Patients with Biliary Atresia: A Systematic Review and Meta-Analysis
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Jahangirnia A, Oltean I, Nasr Y, Islam N, Weir A, Nanassy Jd, Nasr A, Demellawy DE
- KMID: 2533199
- Pediatr Gastroenterol Hepatol Nutr.
- 2022 Sep;25(5):353-375.
- doi: 10.5223/pghn.2022.25.5.353
No systematic review to date has examined histopathological parameters in relation to native liver survival in children who undergo the Kasai operation for biliary atresia (BA). A systematic review and meta-analysis... -
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- Fibrotic Burden Determines Cardiovascular Risk among Subjects with Metabolic Dysfunction-Associated Fatty Liver Disease
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Han E, Lee Yh, Lee JS, Lee HW, Kim BK, Park JY, Kim DY, Ahn SH, Lee BW, Kang ES, Cha BS, Kim SU
- KMID: 2533187
- Gut Liver.
- 2022 Sep;16(5):786-797.
- doi: 10.5009/gnl210290
Background/Aims: Metabolic dysfunction associated fatty liver disease (MAFLD) has recently been introduced to compensate for the conventional concept of nonalcoholic fatty liver disease (NAFLD). We explored whether fibrotic burden determines... -
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- A prospective study of the correlation between hepatic fibrosis and noninvasively measured fibrosis markers including serum M2BPGi and acoustic radiation force impulse elastography
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Seo KI, Hwang H, Yun BC, Moon HH, Choi YI, Shin DH, Yoon M
- KMID: 2532045
- Kosin Med J.
- 2022 Jun;37(2):146-153.
- doi: 10.7180/kmj.22.110
Background: Mac-2 binding protein glycosylation isomer (M2BPGi) was introduced as a noninvasively measurable serologic marker for liver fibrosis. Acoustic radiation force impulse imaging (ARFI) elastography is another noninvasive method of... -
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- Effects of interleukin-17 inhibitors on hepatic fibrosis index in patients with psoriasis and metabolic dysfunction-associated fatty liver disease: Directed acyclic graphs
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Takamura S, Teraki Y, Katayama E, Kawaguchi T, Kawaguchi M, Nakano D, Tsutsumi T, Nagoshi S, Nakama T, Torimura T
- KMID: 2528257
- Clin Mol Hepatol.
- 2022 Apr;28(2):269-272.
- doi: 10.3350/cmh.2022.0040
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- A New Murine Liver Fibrosis Model Induced by Polyhexamethylene Guanidine-Phosphate
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Kim M, Hur S, Kim KH, Cho Y, Kim K, Kim HR, Nam KT, Lim KM
- KMID: 2526814
- Biomol Ther.
- 2022 Mar;30(2):126-136.
- doi: 10.4062/biomolther.2021.120
Liver fibrosis is part of the wound healing process to help the liver recover from the injuries caused by various liver-damaging insults. However, liver fibrosis often progresses to life-threatening cirrhosis... -
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- Cardiovascular Risk Is Elevated in Lean Subjects with Nonalcoholic Fatty Liver Disease
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Kim Y, Han E, Lee JS, Lee HW, Kim BK, Kim MK, Kim HS, Park JY, Kim DY, Ahn SH, Lee BW, Kang ES, Cha BS, Lee Yh, Kim SU
- KMID: 2527001
- Gut Liver.
- 2022 Mar;16(2):290-299.
- doi: 10.5009/gnl210084
Background/Aims: Nonalcoholic fatty liver disease (NAFLD) and obesity are independently associated with an increased risk for atherosclerotic cardiovascular disease (ASCVD), the leading cause of mortality in patients with NAFLD. Many... -
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- Human Liver Stem Cell Transplantation Alleviates Liver Fibrosis in a Rat Model of CCl 4 -Induced Liver Fibrosis
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Lee JH, Lee S, Park HJ, Kim YA, Lee SK
- KMID: 2522565
- Int J Stem Cells.
- 2021 Nov;14(4):475-484.
- doi: 10.15283/ijsc21031
Background and Objectives: Mesenchymal stem cells (MSCs) elicit therapeutic effects against liver fibrosis in animal models. Human liver stem cells (HLSCs) are cells isolated from human liver tissue that have... -
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- Severe Phenotype of Non-alcoholic Fatty Liver Disease in Pediatric Patients with Subclinical Hypothyroidism: a Retrospective Multicenter Study from Korea
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Choi SY, Yi DY, Kim SC, Kang B, Choe BH, Lee Y, Lee YM, Lee EH, Jang HJ, Choi YJ, Kim HJ
- KMID: 2516049
- J Korean Med Sci.
- 2021 May;36(20):e137.
- doi: 10.3346/jkms.2021.36.e137
Background: It is uncertain whether non-alcoholic fatty liver disease (NAFLD) is associated with subclinical hypothyroidism (SH) in pediatric patients. The purpose of this study was to investigated the prevalence and... -
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- Diagnostic Efficacy of Serum Mac-2 Binding Protein Glycosylation Isomer and Other Markers for Liver Fibrosis in Non-Alcoholic Fatty Liver Diseases
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Jang SY, Tak WY, Park SY, Kweon YO, Lee YR, Kim G, Hur K, Han MH, Lee WK
- KMID: 2512688
- Ann Lab Med.
- 2021 May;41(3):302-309.
- doi: 10.3343/alm.2021.41.3.302
Background: Mac-2 binding protein glycosylation isomer (M2BPGi) has been established as a non-invasive biomarker for liver fibrosis. We evaluated the diagnostic efficacy of M2BPGi compared with those of other liver... -
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- Analysis of Results of Liver-related Health Care Checkup in Mongolian Immigrants: A Comparison with Results from Koreans
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Kim DH, Lee JK, Kim H, Oh Ac, Hong YJ, Park SC, Kong CB
- KMID: 2525789
- Lab Med Online.
- 2021 Apr;11(2):88-92.
- doi: 10.47429/lmo.2021.11.2.88
Background: The incidence and mortality rate of liver cancer in Mongolians are known to be the highest in the world, and liver cancer in Mongolians is mainly caused by chronic... -
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- Increased Expression of S100B and RAGE in a Mouse Model of Bile Duct Ligation-induced Liver Fibrosis
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Park JW, Kim MJ, Kim SE, Kim HJ, Jeon YC, Shin HY, Park SJ, Jang MK, Kim DJ, Park CK, Choi EK
- KMID: 2514901
- J Korean Med Sci.
- 2021 Apr;36(14):e90.
- doi: 10.3346/jkms.2021.36.e90
Background: Liver fibrosis is defined as the accumulation of the extracellular matrix and scar formation. The receptor for advanced glycation end products (RAGE) has been demonstrated to participate in fibrogenesis.... -
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- Negligible risk of hepatocellular carcinoma in chronic hepatitis B patients in immune-tolerant phase: Myth or fact
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Yip TCF, Wong GLH, Wong VWS
- KMID: 2514767
- Clin Mol Hepatol.
- 2021 Apr;27(2):273-277.
- doi: 10.3350/cmh.2021.0019
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