Investig Clin Urol.  2020 Feb;61(Suppl 1):S43-S50. 10.4111/icu.2020.61.S1.S43.

The human gastrointestinal microbiota and prostate cancer development and treatment

Affiliations
  • 1Dartmouth Medical School, Hanover, NH, USA. Sybil.T.Sha.MED@dartmouth.edu
  • 2University of Central Florida, Orlando, FL, USA.
  • 3University of East Anglia, Norwich, UK.
  • 4Central Florida Cancer Institute, Davenport, FL, USA.

Abstract

The human gastrointestinal microbiome contains commensal bacteria and other microbiota that have been gaining increasing attention in the context of cancer development and response to treatment. Microbiota play a role in the maintenance of host barrier surfaces that contribute to both local inflammation and other systemic metabolic functions. In the context of prostate cancer, the gastrointestinal microbiome may play a role through metabolism of estrogen, an increase of which has been linked to the induction of prostatic neoplasia. Specific microbiota such as Bacteroides, Streptococcus, Bacteroides massiliensis, Faecalibacterium prausnitzii, Eubacterium rectalie, and Mycoplasma genitalium have been associated with differing risks of prostate cancer development or extensiveness of prostate cancer disease. In this Review, we discuss gastrointestinal microbiota's effects on prostate cancer development, the ability of the microbiome to regulate chemotherapy for prostate cancer treatment, and the importance of using Next Generation Sequencing to further discern the microbiome's systemic influence on prostate cancer.

Keyword

Microbiota; Prostatic neoplasms

MeSH Terms

Bacteria
Bacteroides
Drug Therapy
Estrogens
Eubacterium
Gastrointestinal Microbiome*
Humans*
Inflammation
Metabolism
Microbiota
Mycoplasma genitalium
Prostate*
Prostatic Neoplasms*
Streptococcus
Estrogens
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