J Clin Neurol.  2020 Jan;16(1):66-74. 10.3988/jcn.2020.16.1.66.

Subtypes of Sleep Disturbance in Parkinson's Disease Based on the Cross-Culturally Validated Korean Version of Parkinson's Disease Sleep Scale-2

Affiliations
  • 1Department of Neurology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
  • 2Deparment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
  • 3Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
  • 4Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 5Department of Neurology, Kyung Hee University College of Medicine, Seoul, Korea.
  • 6Department of Neurology, Dong-A University College of Medicine, Busan, Korea.
  • 7Department of Neurology and Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 8Department of Neurology, Hallym University College of Medicine, Anyang, Korea.
  • 9Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea.
  • 10Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
  • 11Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 12Department of Neurology, Parkinson/Alzheimer Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 13Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • 14Department of Neurology, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
  • 15Department of Neurology, Gachon University Gil Hospital, College of Medicine, Gachon University, Incheon, Korea.
  • 16Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
  • 17Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • 18Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, College of Medicine, Seoul National University, Seoul, Korea.
  • 19Department of Neurology, Chungbuk National University School of Medicine, Chungbuk National University Hospital, Cheongju, Korea.
  • 20Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea.
  • 21Department of Neurology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
  • 22Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, Korea.
  • 23Department of Neurology, Bobath Memorial Hospital, Seongnam, Korea.
  • 24Department of Neurology, Chungnam National University School of Medicine, Chungnam National University Hospital, Daejeon, Korea.
  • 25Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 26Department of Neurology, Keimyung University School of Medicine, Daegu, Korea.
  • 27Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine, Seoul, Korea.
  • 28Department of Neurology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • 29Department of Neurology, Hanyang University College of Medicine, Seoul, Korea.
  • 30Department of Neurology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. jsk502@hotmail.com
  • 31Dementia and Neurodegenerative Disease Research Center, Inje University, Busan, Korea.

Abstract

BACKGROUND
AND PURPOSE: This study aimed to determine the clinimetric properties of the Korean version of Parkinson's Disease Sleep Scale-2 (K-PDSS-2) and whether distinct subtypes of sleep disturbance can be empirically identified in patients with Parkinson's disease (PD) using the cross-culturally validated K-PDSS-2.
METHODS
The internal consistency, test-retest reliability, scale precision, and convergent validity of K-PDSS-2 were assessed in a nationwide, multicenter study of 122 patients with PD. Latent class analysis (LCA) was used to derive subgroups of patients who experienced similar patterns of sleep-related problems and nocturnal disabilities.
RESULTS
The total K-PDSS-2 score was 11.67±9.87 (mean±standard deviation) at baseline and 12.61±11.17 at the retest. Cronbach's α coefficients of the total K-PDSS-2 scores at baseline and follow-up were 0.851 and 0.880, respectively. The intraclass correlation coefficients over the 2-week study period ranged from 0.672 to 0.848. The total K-PDSS-2 score was strongly correlated with health-related quality of life measures and other corresponding nonmotor scales. LCA revealed three distinct subtypes of sleep disturbance in the study patients: "less-troubled sleepers,""PD-related nocturnal difficulties," and "disturbed sleepers."
CONCLUSIONS
K-PDSS-2 showed good clinimetric attributes in accordance with previous studies that employed the original version of the PDSS-2, therefore confirming the cross-cultural usefulness of the scale. This study has further documented the first application of an LCA approach for identifying subtypes of sleep disturbance in patients with PD.

Keyword

Parkinson disease; sleep; Parkinson's Disease Sleep Scale-2; Korean version; validity; latent class analysis

MeSH Terms

Follow-Up Studies
Humans
Parkinson Disease*
Quality of Life
Weights and Measures
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