J Mov Disord.  2016 May;9(2):114-119. 10.14802/jmd.15039.

Rapid Eye Movement Sleep Behavior Disorder in Parkinson's Disease: A Preliminary Study

Affiliations
  • 1College of Medicine, Gachon University, Incheon, Korea.
  • 2Department of Neurology, College of Medicine, Gachon University, Incheon, Korea. khpark@gachon.ac.kr

Abstract


OBJECTIVE
Rapid eye movement sleep behavior disorder (RBD) is associated with α-synucleinopathies, such as Parkinson's disease (PD). We aimed to assess the differences in the clinical characteristics of PD with and without RBD.
METHODS
Forty-two patients previously diagnosed with PD were evaluated for clinical history, motor and cognitive functioning using the Unified Parkinson's Disease Rating Scale (UPDRS) and Mini-Mental State Examination (MMSE), autonomic symptoms, sleep characteristics using the Pittsburg Sleep Quality Index (PSQI), and the presence of RBD using the Korean version of the RBD screening questionnaire (RBDSQ). The prevalence of RBD and the patients' demographic features were evaluated. The patients were classified into two groups, PD with RBD and PD without RBD, based on the RBDSQ scores. The motor and cognitive functions, as well as other clinical features of the two groups were compared.
RESULTS
A total of 42 PD patients were enrolled. Eighteen patients were classified as PD with RBD. Compared to PD without RBD, PD with RBD showed higher scores of rigidity in the UPDRS subscale. Regarding sleep problems, PD with RBD revealed higher sleep disturbance, lower sleep efficiency, and lower overall sleep quality in the PSQI. There was no difference in cognitive dysfunction between the two groups according to the Korean version of the MMSE.
CONCLUSIONS
PD with RBD was associated with poorer sleep and motor symptoms. Therefore, RBD symptoms in PD are possibly poor prognostic markers.

Keyword

Rapid eye movement sleep behavior disorder; Parkinson disease; Rapid eye movement screening questionnaire; Unified Parkinson's Disease Rating Scale; Pittsburg Sleep Quality Index
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