Korean J Sports Med.  2018 Mar;36(1):7-14. 10.5763/kjsm.2018.36.1.7.

The Association between Muscle Strength and Hyperuricemia in the Healthy Middle-aged Adult in Yangpyeong Province

  • 1Department of Physical Education, College of Education, Seoul National University, Seoul, Korea. kys0101@snu.ac.kr
  • 2Divison of Nephrology, Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Korea.
  • 3Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • 4Institute of Sport Science, Seoul National University, Seoul, Korea.


This study aimed to examine the prevalence of hyperuricemia in association with relative grip strength and leg strength in Korean Elderly.
We studied cross-sectional analysis with 1,894 rural adults (40–88 years old), who were surveyed for 7 years from 2007 to 2014. Grip strength was measured by using Takei grip strength dynamometer. Leg strength was measured by using Takei leg strength dynamometer. Hyperuricemia was defined by examining serum uric acid concentration (male ≥7 mg/dL, female ≥6 mg/dL). Logistic regression was conducted to evaluate the association of grip strength and leg strength with hyperuricemia (p < 0.05).
Subjects who reported high level of relative grip strength had a significantly lower odds ratio (OR) of hyperuricemia than subjects who reported low level of relative grip strength (OR, 0.37; 95% confidence interval [CI], 0.16–0.84). When it comes to sex, subjects both high relative muscle strength are significantly lower multivariate-adjusted OR of hyperuricemia than subjects both low relative muscle strength in male (OR, 0.52; 95% CI, 0.29–0.95) and female (OR, 0.47; 95% CI, 0.26–0.95). Additionally, senior group (age ≥65 years), who have low relative grip strength and high relative leg strength, was only significantly associated with the prevalence of hyperuricemia (OR, 0.43; 95% CI, 0.19–0.98).
The relationship between hyperuricemia and relative grip strength may be mediated through decreased estimated glomerular filtration ratio. Therefore, muscle strength is important factor in prevention of renal vascular dysfunction which is a risk factor of hyperuricemia, and resistance exercise is needed to improve muscle strength.


Exercise; Glomerular filtration rate; Hand strength; Hyperuricemia; Muscle strength
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