J Korean Geriatr Psychiatry.  2019 Nov;23(2):45-50. 10.0000/jkgp.2019.23.2.45.

Plasma Fibrinogen and C-Reactive Protein Levels in Alzheimer's Disease and Mild Cognitive Impairment

  • 1Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. lkj@paik.ac.kr


The aim of this study was to measure and compare the levels of fibrinogen and C-reactive protein (CRP) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) groups and to investigate the correlations between blood-based inflammatory factors and cognitive functions.
Seventy one subjects participated in this study [AD : 28, MCI : 23, normal control (NC) : 20]. The overall cognitive function of the subjects and the severity of the disease stage were assessed using Mini-Mental Status Examination in the Korean Version of the the CERAD Assessment Packet (MMSE-KC), Global Deterioration Scale (GDS), Clinical Dementia Rating (CDR), Korean neuropsychiatric inventory (K-NPI) and Geriatric Depression Scale (K-GDS). Plasma fibrinogen and CRP were also measured in AD, MCI, and NC groups.
Fibrinogen and CRP levels were not significantly different among AD, MCI, and NC groups. Fibrinogen and CRP did not show a significant correlation with MMSE-KC, CDR, GDS, K-NPI and K-GDS scores.
In this study, it was found that plasma fibrinogen and CRP did not increase as cognitive function decreased. But this study was the first meaningful study in Korea about the relationship between cognitive impairment and plasma fibrinogen and CRP levels. It is necessary to conduct prospective cohort studies on more patients in the future.


Alzheimer's disease; Mild cognitive impairment; Fibrinogen; C-reactive protein
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