Clin Pediatr Hematol Oncol.
2019 Oct;26(2):105-109. 10.15264/cpho.2019.26.2.105.
Embryonal Carcinoma of the Pineal Gland Developed in an Adolescent Boy with Klinefelter Syndrome
- Affiliations
-
- 1Department of Pediatrics, Yeungnam University Hospital, Daegu, Korea. fortune001j@gmail.com, mopic@hanmail.net
- 2Department of Pathology, Yeungnam University Hospital, Daegu, Korea.
- KMID: 2464259
- DOI: http://doi.org/10.15264/cpho.2019.26.2.105
Abstract
- Klinefelter syndrome (KS) is characterized by small testes, gynecomastia, tall stature, and hypergonadotropic hypogonadism. This condition is associated with extra X chromosomes. It is well known that these aneuploidies predispose individuals to the development of several cancers. Moreover, there are many case reports that show KS patients to have a higher relative risk for the development of malignancy. However, incracranial germ cell tumor (ICGCT) associated with KS is very uncommon. Herein, we report delayed diagnosis of KS in a 15-year-old boy with ICGCT, embryonal carcinoma of the pineal gland, after multimodality treatment in Korea.
