Cancer Res Treat.  2019 Oct;51(4):1666-1670. 10.4143/crt.2019.022.

Diffuse Large B-Cell Lymphoma Arising within Ileal Neobladder: An Expanding Spectrum of Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

Affiliations
  • 1Department of Pathology, Eulji University Hospital, Daejeon, Korea.
  • 2Department of Urology, Eulji University Hospital, Daejeon, Korea. jspark.uro@gmail.com
  • 3Department of Internal Medicine, Eulji University Hospital, Daejeon, Korea.

Abstract

Diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI), specifically arising in ileal neobladder, is a rare neoplasm. We present an unusual case of Epstein-Barr virus (EBV)-positive DLBCL-CI arising within neobladder with detailed clinical, histological, and immunophenotypical features in an immunocompetent patient. An 88-year-old male was admitted for gross hematuria. He had undergone radical cystectomy and ileal neobladder 17 years ago for invasive bladder cancer. Computed tomography showed enhancing lesions on dome and posterior wall of neobladder with mucosal thickening and multiple enlarged retroperitoneal lymphadenopathies. Transurethralresection of neobladder lesion revealed the diffuse infiltration of large lymphoid cells which were positive for CD20, CD30, and multiple myeloma oncogen-1 with EBV-encoded small RNAs co-localizing, and diagnosis of EBV-positive DLBCL-CI was made. After multi-agent chemotherapy, the lesion disappeared. We suggest that clinicians should consider the possibility of DLBCL-CI in patients presented with hematuria during follow-up after bladder reconstruction.

Keyword

Diffuse large B-cell lymphoma; Epstein–Barr virus; Ileal neobladder; Bladder reconstruction; Radical cystectomy

MeSH Terms

Aged, 80 and over
B-Lymphocytes*
Cystectomy
Diagnosis
Drug Therapy
Follow-Up Studies
Hematuria
Humans
Inflammation*
Lymphocytes
Lymphoma, B-Cell*
Male
Multiple Myeloma
RNA
Urinary Bladder
Urinary Bladder Neoplasms
RNA
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