Yeungnam Univ J Med.  2019 May;36(2):155-158. 10.12701/yujm.2019.00115.

Imatinib-induced hepatitis treated by corticosteroids in a patient with metastatic gastrointestinal stromal tumor

• Kang MK
• Lee HJ
• Choi JH

• KMID: 2449330
• DOI: http://doi.org/10.12701/yujm.2019.00115

Abstract

Imatinib mesylate is currently used as the first-line treatment for metastatic gastrointestinal stromal tumors (GISTs). Imatinib-induced hepatotoxicity in patients with GIST is very rare. Its features vary from subclinical elevation of serum aminotransferase to clinically apparent acute hepatitis, which is associated with immunologic reactions. Imatinib-induced hepatotoxicity with autoimmune-like features can be treated by the discontinuation of imatinib mesylate and the administration of oral steroids. Here, we report a case of late-onset imatinib-induced hepatitis with autoimmune-like features in a patient with metastatic GIST, which was improved by oral corticosteroids.

Keyword

Corticosteroids; Drug-induced liver injury; Gastrointestinal stromal tumors; Imatinib mesylate

MeSH Terms

Adrenal Cortex Hormones*
Drug-Induced Liver Injury
Gastrointestinal Stromal Tumors*
Hepatitis*
Humans
Imatinib Mesylate
Steroids
Adrenal Cortex Hormones
Imatinib Mesylate
Steroids