Korean J Pancreas Biliary Tract.  2015 Jan;20(1):27-43. 10.15279/kpba.2015.20.1.27.

Predictive Factors of Malignant Potential in Gallbladder Polyps

  • 1Division of Gastroenterology, Department of Internal Medicine, Jeonju, Korea. solee@jbnu.ac.kr
  • 2Department of Surgery, Chonbuk National University Medical School and Hospital, Jeonju, Korea.


Although the incidence of GB polyps is increasing with improved surveillance, the study of predictive factors of malignant potential has not been sufficient. The aim of this retrospective study is to investigate the predictive factors of malignant potential in GB polyps.
Among 3,159 patients with laparoscopic cholecystectomy in Chonbuk National University hospital January 2009 to December 2013, 437 patients confirmed GB polyps pathologically were enrolled. The patients were divided into two groups; one with benign GB polyp and another with GB adenoma and incidental GB cancer.
Group I with benign GB polyp was seen in 359 patients. On the other hand, 53 patients with GB adenoma and 25 patients with GB cancer in gourp II were identified. The patients in group II had shown a significantly higher incidence of age older than 50 years (53/78, 67.9% vs. 163/359, 45.4%, p=0.001), size larger than 10mm (40/78, 51.3% vs. 37/359, 10.3%, p<0.001), and GB wall thickening (36/78, 46.2% vs. 77/359, 21.5%, p<0.001). The presence of GB stone had not shown significant differences between two groups (26/78, 33.3% vs. 96/359, 26.7%, p=0.378).
Cholecystectomy should be considered for the patients with GB polyp with these predictive factors.


Gallbladder neoplasm; Gallbladder cancer; Risk factors
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