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Picropodophyllotoxin Inhibits Cell Growth and Induces Apoptosis in Gefitinib-Resistant Non-Small Lung Cancer Cells by Dual-Targeting EGFR and MET

Lee JY, Kang BY, Jung SJ, Kwak AW, Lee SO, Park JW, Joo SH, Yoon G, Lee MH, Shim JH

Patients with non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) amplification or sensitive muta-tions initially respond to the tyrosine kinase inhibitor gefitinib, however, the treatment becomes less effective...
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Bacterial Co-Infection and Empirical Antibacterial Therapy in Patients With COVID-19

Lee J, Chang E, Jung J, Kim MJ, Chong YP, Kim SH, Lee SO, Choi SH, Kim YS, Bae S

Background: The rate and composition of bacterial co-infection in patients with coronavirus disease 2019 (COVID-19) were evaluated when microbiological testing was conducted on the majority of patients. We also evaluated...
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Safety and outcome of treatment of latent tuberculosis infection liver transplant recipients

Lee YW, Chung H, Kim SH, Sung H, Ha SM, Jwa EK, Jung DH, Moon DB, Lee SG, Lee SO

Background: There are limited data on the outcome and tolerability of latent tuberculosis infection (LTBI) treatment in liver trans-plant. We performed a retrospective cohort study of screening and treatment of...
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Nationwide survey of infection prevention protocols in solid organ transplantation in South Korea

Huh K, Jeong SJ, Kim YJ, Kang JM, Kim JM, Park WB, Ahn HJ, Yang J, Kim SI, Kwon OJ, Kim MS, Lee SO

Background: Infections are a major cause of morbidity, graft failure, and mortality in solid organ transplant recipients. Preventive measures have greatly reduced the burden of posttransplant infections. However, little is known...
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Infection patterns during the first year after adult liver transplantation: a retrospective analysis

Yun JS, Jeong JS, Lee SO, Hwang S

Background: Infection is one of the most significant possible complications after liver transplantation (LT). This study identified patterns of infection and compared the characteristics of patients with and without infections during...
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Ten-Year Trends of Hepatitis A Seroprevalence in People Living with HIV in Korea

Lee S, Lee JE, Lee SO, Sim YK, Lee SH

Epidemiological information on hepatitis A among people living with HIV (PLHIV) in Korea is scarce. This retrospective study was performed at a tertiary care hospital and included 756 PLHIV with...
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COVID-19 among solid organ transplant recipients in Korea: surveillance data of the Korean Transplantation Society, January 2020 to March 2022

Kang JM, Kim YJ, Huh K, Kim JM, Park WB, Ahn HJ, Yang J, Lee SO, Jeong SJ, Kim MS, Kim SI

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Fluvoxamine Treatment of Patients with Symptomatic COVID-19 in a Community Treatment Center: A Preliminary Result of Randomized Controlled Trial

Seo H, Kim H, Bae S, Park S, Chung H, Sung Hs, Jung J, Kim MJ, Kim SH, Lee SO, Choi SH, Kim YS, Son KY, Chong YP

Background: This study aimed to evaluate whether fluvoxamine reduces clinical deterioration in adult patients with mild to moderate coronavirus disease 2019 (COVID-19), and to identify risk factors for clinical deterioration...
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Korean National Healthcare-associated Infections Surveillance System, Intensive Care Unit Module Report: Summary of Data from July 2019 through June 2020

Kim EJ, Kwak YG, Kwak SH, Ko SH, Kweon OM, Kim ES, Kim JH, Kim TH, Kim TS, Moon HW, Park SH, Ahn JY, Yoo SY, Yoo HM, Lee SO, Cho NH, Choe PG, Hong KH, Lee YM, Lee MS

Background: This report presents the annual data of the intensive care unit (ICU) module of the Korean National Healthcare-associated Infections Surveillance System (KONIS) between July 2019 and June 2020. Methods: We...
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Antimicrobial Susceptibility Trends and Risk Factors for Antimicrobial Resistance in Pseudomonas aeruginosa Bacteremia: 12-Year Experience in a Tertiary Hospital in Korea

Kang JS, Moon C, Mun SJ, Lee JE, Lee SO, Lee S, Lee SH

Background: Infections caused by multidrug-resistant Pseudomonas aeruginosa (MDRPA) have been on the rise worldwide, and delayed active antimicrobial therapy is associated with high mortality. However, few studies have evaluated increases...
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Risk Factors for Mortality in Patients with Klebsiella pneumoniae Carbapenemaseproducing K. pneumoniae and Escherichia coli bacteremia

Seo H, Bae S, Kim MJ, Chong YP, Kim SH, Lee SO, Choi SH, Kim YS, Jung J

Background: Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacterales bacteremia is associated with significant mortality; however, no optimal antibiotic strategy is available. We aimed to evaluate the clinical outcomes according to the antibiotic...
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Predicting the Severity of Acute Pancreatitis

Yu SY, Lee YC, Kim SH, Lee SO

Acute pancreatitis has two mortality peaks, which occurs within the first 2 weeks due to organ failure and then weeks or months later as result of multi-organ failure and local...
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Infectious Causes of Eosinophilic Meningitis in Korean Patients: A Single-Institution Retrospective Chart Review from 2004 to 2018

Park S, Jung J, Chong YP, Kim SH, Lee SO, Choi SH, Kim YS, Kim MJ

Eosinophilic meningitis is defined as the presence of more than 10 eosinophils per μl in the cerebrospinal fluid (CSF), or eosinophils accounting for more than 10% of CSF leukocytes in...
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The First Case of Multisystem Inflammatory Syndrome in Adult after COVID-19 in Korea

Chung H, Seo H, Park S, Kim H, Jung J, Chong YP, Kim SH, Lee SO, Choi SH, Kim YS, Kim MJ

Multisystem inflammatory disease in children is a Kawasaki disease like illness occurring after severe acute respiratory syndrome coronavirus 2 infection in children. As the pandemic progresses, similar syndromes were also...
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A Longitudinal Study of Adult Patients with Staphylococcus aureus Bacteremia over 11 Years in Korea

Choi SH, Lee J, Jung J, Kim ES, Kim MJ, Chong YP, Kim SH, Lee SO, Choi SH, Woo JH, Kim YS

Background: The temporal changes in the Staphylococcus aureus genotypes causing S. aureus bacteremia (SAB) and the corresponding clinical changes over the last decade in South Korea are rarely investigated. Methods: A longitudinal...
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Korean National Healthcare-associated Infections Surveillance System, Intensive Care Unit Module Report: Summary of Data from July 2018 to June 2019

Kim EJ, Kwak YG, Kwak SH, Ko SH, Kim JH, Kim ES, Kim TH, Ryu SY, Moon HW, Park SH, Ahn JY, Yoo SY, Yoo HM, Yun NR, Lee MS, Lee SO, Cho Nh, Choi Jy, Hong KH, Choi YH, Kim MN

Background: In this report, we present the annual data of the intensive care unit (ICU) module of the Korean National Healthcare-associated Infections Surveillance (KONIS) System from July 2018 to June...
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Infections in Lung Transplant Recipients during and after Prophylaxis

Bae M, Lee SO, Jo KW, Choi S, Lee J, Chae EJ, Do KH, Choi DK, Choi IC, Hong SB, Shim TS, Kim HR, Kim DK, Park SI

Background: The timeline of infections after lung transplantation has been changed with the introduction of new immunosuppressants and prophylaxis strategies. The study aimed to investigate the epidemiological characteristics of infectious...
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Osteonecrosis of the Femoral Head in Korean Patients with Human Immunodeficiency Virus Infection

Lee SO, Lee JE, Lee S, Lee SH, Kang JS, Lee IS, Moon NH

Background: Osteonecrosis of the femoral head (ONFH) is a disabling condition that often necessitates total hip arthroplasty (THA). Although ONFH occurs more frequently among patients with human immunodeficiency virus (HIV)...
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Effect of Cancer Awareness on Treatment Decision for Pancreatic Cancer Patients

Lee EJ, Seo SY, Kim IH, Kim SW, Lee SO, Lee ST, Kim SH

Background/Aims: With recent changes in the treatment of pancreatic cancer, patients’ active decision-making has become more important. Nevertheless, it is difficult to give patients proper insights into the disease. The...
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Diagnostic usefulness of the cytomegalovirus (CMV)-specific T cell-based assay for predicting CMV infection after kidney transplant

Kim T, Lee HJ, Kim SM, Jung JH, Shin S, Kim YH, Sung H, Chong YP, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH, Han DJ

Background/Aims: We evaluated the usefulness in kidney transplant (KT) candidates of cytomegalovirus (CMV)-specific enzyme-linked immunospot (ELISPOT) assays for predicting the development of post-transplant CMV infections. Methods: All adult recipients admitted for...
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