Allergy Asthma Immunol Res.  2018 Nov;10(6):716-721. 10.4168/aair.2018.10.6.716.

Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children

  • 1Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
  • 2Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
  • 3Research and Development Unit, Shino-Test Corporation, Sagamihara, Japan.
  • 4Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
  • 5Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.


Epidemiological studies have shown that exposure to tobacco smoke causing irritation and inflammation in the airways tends to reduce serum periostin concentrations in adults. We now investigate prospective cross-sectional study on 135 Korean students aged 7 years in the first grade who were participating in the Seongnam Atopy Project for Children's Happiness 2016 (SAP2016) cohort. To the best of our knowledge, this is the first study to show significant inverse correlations between serum periostin concentration and exposure to xylene and formaldehyde in children. Our findings suggested the need for caution in using the serum periostin level as a marker for allergic diseases, since exposure to volatile organic compounds and formaldehyde may confound the interpretation of these results.


Periostin; volatile organic compounds; formaldehyde; children

MeSH Terms

Cohort Studies
Cross-Sectional Studies
Epidemiologic Studies
Prospective Studies
Volatile Organic Compounds*
Volatile Organic Compounds


  • Figure Associations between serum periostin concentrations and quarter of urinary concentrations of (A) p-toluic acid and (B) TZCA in 7-year-old children (n = 135). Data are presented as GMs with GSD (T bars). GM, geometric mean; GSD, geometric standard deviation; TZCA, thiazolidine-4-carboxylic acid.

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Eun Kyo Ha, Ju Hee Kim, Dawon Park, Eun Lee, Seung Won Lee, Hye Mi Jee, Youn Ho Shin, Man Yong Han
J Korean Med Sci. 2022;37(8):e63.    doi: 10.3346/jkms.2022.37.e63.


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