Allergy Asthma Immunol Res.  2018 Nov;10(6):716-721. 10.4168/aair.2018.10.6.716.

Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children

• Yon DK
• An J
• Ha EK
• Jee HM
• Izuhara K
• Ono J
• Jung YH
• Lee KS
• Sheen YH
• Baek H
• Han MY

• KMID: 2441819
• DOI: http://doi.org/10.4168/aair.2018.10.6.716

Abstract

Epidemiological studies have shown that exposure to tobacco smoke causing irritation and inflammation in the airways tends to reduce serum periostin concentrations in adults. We now investigate prospective cross-sectional study on 135 Korean students aged 7 years in the first grade who were participating in the Seongnam Atopy Project for Children's Happiness 2016 (SAP2016) cohort. To the best of our knowledge, this is the first study to show significant inverse correlations between serum periostin concentration and exposure to xylene and formaldehyde in children. Our findings suggested the need for caution in using the serum periostin level as a marker for allergic diseases, since exposure to volatile organic compounds and formaldehyde may confound the interpretation of these results.

Keyword

Periostin; volatile organic compounds; formaldehyde; children

MeSH Terms

Adult
Child*
Cohort Studies
Cross-Sectional Studies
Epidemiologic Studies
Formaldehyde*
Gyeonggi-do
Happiness
Humans
Inflammation
Prospective Studies
Smoke
Tobacco
Volatile Organic Compounds*
Xylenes
Formaldehyde
Smoke
Volatile Organic Compounds
Xylenes

Figure

• 

  Figure Associations between serum periostin concentrations and quarter of urinary concentrations of (A) p-toluic acid and (B) TZCA in 7-year-old children (n = 135). Data are presented as GMs with GSD (T bars). GM, geometric mean; GSD, geometric standard deviation; TZCA, thiazolidine-4-carboxylic acid.

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