Allergy Asthma Immunol Res.  2018 Nov;10(6):716-721. 10.4168/aair.2018.10.6.716.

Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children

Affiliations
  • 1Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea. drmesh@gmail.com
  • 2Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
  • 3Research and Development Unit, Shino-Test Corporation, Sagamihara, Japan.
  • 4Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
  • 5Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. paviola7@gmail.com

Abstract

Epidemiological studies have shown that exposure to tobacco smoke causing irritation and inflammation in the airways tends to reduce serum periostin concentrations in adults. We now investigate prospective cross-sectional study on 135 Korean students aged 7 years in the first grade who were participating in the Seongnam Atopy Project for Children's Happiness 2016 (SAP2016) cohort. To the best of our knowledge, this is the first study to show significant inverse correlations between serum periostin concentration and exposure to xylene and formaldehyde in children. Our findings suggested the need for caution in using the serum periostin level as a marker for allergic diseases, since exposure to volatile organic compounds and formaldehyde may confound the interpretation of these results.

Keyword

Periostin; volatile organic compounds; formaldehyde; children

MeSH Terms

Adult
Child*
Cohort Studies
Cross-Sectional Studies
Epidemiologic Studies
Formaldehyde*
Gyeonggi-do
Happiness
Humans
Inflammation
Prospective Studies
Smoke
Tobacco
Volatile Organic Compounds*
Xylenes
Formaldehyde
Smoke
Volatile Organic Compounds
Xylenes

Figure

  • Figure Associations between serum periostin concentrations and quarter of urinary concentrations of (A) p-toluic acid and (B) TZCA in 7-year-old children (n = 135). Data are presented as GMs with GSD (T bars). GM, geometric mean; GSD, geometric standard deviation; TZCA, thiazolidine-4-carboxylic acid.


Cited by  1 articles

Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren
Eun Kyo Ha, Ju Hee Kim, Dawon Park, Eun Lee, Seung Won Lee, Hye Mi Jee, Youn Ho Shin, Man Yong Han
J Korean Med Sci. 2022;37(8):e63.    doi: 10.3346/jkms.2022.37.e63.


Reference

1. Izuhara K, Ohta S, Ono J. using periostin as a biomarker in the treatment of asthma. Allergy Asthma Immunol Res. 2016; 8:491–498.
Article
2. James A, Janson C, Malinovschi A, Holweg C, Alving K, Ono J, et al. Serum periostin relates to type-2 inflammation and lung function in asthma: data from the large population-based cohort Swedish GA(2)LEN. Allergy. 2017; 72:1753–1760.
3. Thomson NC, Chaudhuri R, Spears M, Haughney J, McSharry C. Serum periostin in smokers and never smokers with asthma. Respir Med. 2015; 109:708–715.
Article
4. Nurmatov UB, Tagiyeva N, Semple S, Devereux G, Sheikh A. Volatile organic compounds and risk of asthma and allergy: a systematic review. Eur Respir Rev. 2015; 24:92–101.
Article
5. Yon DK, Jee HM, Ha EK, Lee SJ, Jung YH, Lee KS, et al. Small airway bronchodilator response to different doses of salbutamol in 7-year-old children. Respir Res. 2017; 18:148.
Article
6. Yon DK, Ha EK, Lee SY, Kim WK, Park YM, Kim J, et al. Hepatitis B immunogenicity after a primary vaccination course associated with childhood asthma, allergic rhinitis, and allergen sensitization. Pediatr Allergy Immunol. 2018; 29:221–224.
Article
7. Yon DK, Lee SW, Ha EK, Lee KS, Jung YH, Jee HM, et al. Serum lipid levels are associated with allergic rhinitis, nasal symptoms, peripheral olfactory function, and nasal airway patency in children. Allergy. 2018.
Article
8. Lee SJ, Ha EK, Jee HM, Lee KS, Lee SW, Kim MA, et al. Prevalence and risk factors of urticaria with a focus on chronic urticaria in children. Allergy Asthma Immunol Res. 2017; 9:212–219.
Article
9. Sung M, Lee KS, Ha EG, Lee SJ, Kim MA, Lee SW, et al. An association of periostin levels with the severity and chronicity of atopic dermatitis in children. Pediatr Allergy Immunol. 2017; 28:543–550.
Article
10. Bae Y, Izuhara K, Ohta S, Ono J, Hong GU, Ro JY, et al. Periostin and interleukin-13 are independently related to chronic spontaneous urticaria. Allergy Asthma Immunol Res. 2016; 8:457–460.
Article
11. Mathias PI, B'Hymer C. A survey of liquid chromatographic-mass spectrometric analysis of mercapturic acid biomarkers in occupational and environmental exposure monitoring. J Chromatogr B Analyt Technol Biomed Life Sci. 2014; 964:136–145.
Article
12. Shin HS, Ahn HS, Lee BH. Determination of thiazolidine-4-carboxylates in urine by chloroformate derivatization and gas chromatography-electron impact mass spectrometry. J Mass Spectrom. 2007; 42:1225–1232.
Article
13. Inoue T, Akashi K, Watanabe M, Ikeda Y, Ashizuka S, Motoki T, et al. Periostin as a biomarker for the diagnosis of pediatric asthma. Pediatr Allergy Immunol. 2016; 27:521–526.
Article
14. Ferrando M, Bagnasco D, Varricchi G, Bernardi S, Bragantini A, Passalacqua G, et al. Personalized medicine in allergy. Allergy Asthma Immunol Res. 2017; 9:15–24.
Article
15. Wardzyńska A, Makowska JS, Pawełczyk M, Piechota-Polańczyk A, Kurowski M, Kowalski ML. Periostin in exhaled breath condensate and in serum of asthmatic patients: relationship to upper and lower airway disease. Allergy Asthma Immunol Res. 2017; 9:126–132.
Article
16. Tajiri T, Matsumoto H, Gon Y, Ito R, Hashimoto S, Izuhara K, et al. Utility of serum periostin and free IgE levels in evaluating responsiveness to omalizumab in patients with severe asthma. Allergy. 2016; 71:1472–1479.
17. Mertens TC, van der Does AM, Kistemaker LE, Ninaber DK, Taube C, Hiemstra PS. Cigarette smoke differentially affects IL-13-induced gene expression in human airway epithelial cells. Physiol Rep. 2017; 5:e13347.
Article
18. Audi C, Baïz N, Maesano CN, Ramousse O, Reboulleau D, Magnan A, et al. Serum cytokine levels related to exposure to volatile organic compounds and PM2.5 in dwellings and workplaces in French farmers - a mechanism to explain nonsmoking COPD. Int J Chron Obstruct Pulmon Dis. 2017; 12:1363–1374.
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