J Korean Soc Clin Toxicol.  2018 Dec;16(2):102-107. 10.22537/jksct.16.2.102.

Association between Smoking and Delayed Neuropsychological Sequelae in Acute Carbon Monoxide Poisoning

  • 1Department of Emergency Medicine, College of Medicine, Soonchunhyang University, Bucheon, Korea. zerohwani@gmail.com, brayden0819@hanmail.net


This study examined the association between smoking and delayed neuropsychological sequelae (DNS) in acute carbon monoxide (CO) poisoning.
Patients admitted to the medical center emergency department from March 2016 to March 2017 because of CO poisoning were examined retrospectively. The patients were divided into two groups: DNS and Non-DNS group. Multiple factors were analyzed to explain DNS, which was assessed by motor disturbances, cognitive impairment, dysphagia, Parkinson-like syndromes, epilepsy, and emotional lability in CO poisoning.
A total of 120 patients were included. The factors related to DNS were smoking (pack-years) (p=0.002) and initial carbon monoxide-hemoglobin level (p=0.015). On the other hand, after multivariate logistic regression analysis, smoking (Odds ratio 1.07; 95% CI, 1.02-1.13; p=0.004) was the only factor associated with DNS.
Smoking is a very reliable factor for predicting the occurrence of DNS. A history of smoking in patients who suffer from CO intoxication is important. If a patient smokes, treatment should be started actively and as soon as possible.


Carbon monoxide poisoning; Delayed neuropsychological sequelae; Smoking
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