Korean J Psychosom Med.  2018 Dec;26(2):86-93. 10.22722/KJPM.2018.26.2.86.

Association between Insulin Resistance and Depression in the General Korean Population : Cross Sectional Findings from the National Health and Nutrition Examination Survey

  • 1Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea. sungjinkim@inje.ac.kr


The purpose of this study was to investigate the association between the insulin resistance and depressive mood, suicidal ideation, psychological stress, and quality of life in general Korean population.
We selected 3,613 subjects from the third year's data of 6th Korean National Health and Nutritional Examination Survey. Insulin resistance was evaluated with Homeostatic Model Assessment of Insulin Resistance. Questionnaires on depressive mood, suicidal ideation and psychological stress were conducted. The quality of life was assessed with the EuroQol-5 dimension index. We used correlation and regression analysis for analysis.
The risk of depressive mood and suicidal ideation was significantly higher in the insulin resistance group than in the control group. The risk of psychological stress was significantly higher in the male group with insulin resistance. The EuroQol-5 dimension index showed a negative correlation with insulin resistance. After adjusting for age, sex and body mass index, increased risk of suicidal ideation was identified only.
We confirmed that insulin resistance is associated to mental health problems related with depression in Korean adults.


Depression; Insulin resistance; Quality of life; Suicidal ideation
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