Ann Dermatol.  2019 Feb;31(1):29-36. 10.5021/ad.2019.31.1.29.

Usefulness of the Psoriatic Arthritis Screening and Evaluation Questionnaire to Monitor Disease Activity in Management of Patients with Psoriasis: Findings from the EPI-PSODE Study

Affiliations
  • 1Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.
  • 2Department of Dermatology, The Catholic University of Korea, Bucheon St. Mary's Hospital, Bucheon, Korea.
  • 3Medical Affairs, Janssen Korea, Seoul, Korea.
  • 4Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • 5Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 6Department of Dermatology, Pusan National University School of Medicine, Busan, Korea.
  • 7Department of Dermatology, Chung-Ang University Hospital, Seoul, Korea.
  • 8Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea.
  • 9Department of Dermatology, Catholic University of Daegu School of Medicine, Daegu, Korea.
  • 10Department of Dermatology, Kyung Hee University Medical Center, Seoul, Korea.
  • 11Department of Dermatology, National Medical Center, Seoul, Korea.
  • 12Department of Dermatology, Kyungpook National University Hospital, Daegu, Korea.
  • 13Department of Dermatology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 14Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.
  • 15Department of Dermatology, Hanyang University Medical Center, Seoul, Korea.
  • 16Department of Dermatology, Korea University Guro Hospital, Seoul, Korea.
  • 17Department of Dermatology, Chosun University Hospital, Gwangju, Korea.
  • 18Department of Dermatology, Wonju Severance Christian Hospital, Wonju, Korea.
  • 19Department of Dermatology, Chungbuk National University College of Medicine, Cheongju, Korea.
  • 20Department of Dermatology, Chonnam National University Hospital, Gwangju, Korea.
  • 21Department of Dermatology, Kosin University College of Medicine, Busan, Korea.
  • 22Department of Dermatology, Dong-A University Hospital, Busan, Korea.
  • 23Department of Dermatology, Dankook University Hospital, Cheonan, Korea.
  • 24Department of Dermatology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
  • 25Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. cjhamc@naver.com

Abstract

BACKGROUND
Psoriasis and psoriatic arthritis (PsA) are included in the group of immune-mediated inflammatory diseases (IMIDs) caused by systemic inflammation; however, indicators for monitoring inflammatory activity in patients with psoriasis, such as the Psoriasis Area and Severity Index (PASI), are limited.
OBJECTIVE
To determine whether the Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire can be used to monitor disease activity in patients with psoriasis.
METHODS
This was a multicenter, noninterventional, cross-sectional study. Demographic factors and PASI and PASE scores were collected to investigate associations between each.
RESULTS
PASE data were available for 1,255 patients, of whom 498 (39.7%) had a score of ≥37. Compared with the group with PASE score < 37, the group with score ≥37 had a higher proportion of women (34.9% vs. 48.8%, p < 0.0001), older mean age at diagnosis (36.4 vs. 41.7 years, p < 0.0001), more severe disease activity using PASI and body surface area measures (p=0.0021 and p=0.0008, respectively), and higher mean body mass index (23.7 vs. 24.1, p=0.0411). In a multiple linear regression model, PASE score was positively associated with cutaneous disease activity (p < 0.0001).
CONCLUSION
After risk-adjustment, PASE was positively associated with PASI, which suggests that PASE can be sensitive to disease activity. Since psoriasis is regarded as one of the IMIDs, PASE may be utilized as a tool not only to screen PsA but also to monitor disease activity.

Keyword

Arthritis; Psoriatic

MeSH Terms

Arthritis
Arthritis, Psoriatic*
Body Mass Index
Body Surface Area
Cross-Sectional Studies
Demography
Diagnosis
Female
Humans
Inflammation
Linear Models
Mass Screening*
Psoriasis*

Figure

  • Fig. 1 Proportion of patients by PASE cut-off values. PASE: Psoriatic Arthritis Screening and Evaluation.

  • Fig. 2 Comparisons in symptom subscale of PASE. PASE: Psoriatic Arthritis Screening and Evaluation.

  • Fig. 3 Comparisons in function subscale of PASE. PASE: Psoriatic Arthritis Screening and Evaluation.


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