Asia Pac Allergy.
2018 Jan;8(1):e6. 10.5415/apallergy.2018.8.e6.
Changes in basophil activation during immunotherapy with house dust mite and mugwort in patients with allergic rhinitis
- Affiliations
-
- 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea. addchang@snu.ac.kr
- 2Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 03080, Korea.
- 3Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea.
- 4Biomedical Research Institute, Seoul National University Bundang Hospital, Seongnam 13620, Korea.
- 5Department of Internal Medicine, Kangdong Sacred Heart Hospital, Seoul 05355, Korea.
- 6Department of Internal Medicine, Korea University Medical Center Anam Hospital, Seoul 02841, Korea.
- 7Department of Internal Medicine, The Armed Forces Capital Hospital, Seongnam 13574, Korea.
- KMID: 2428873
- DOI: http://doi.org/10.5415/apallergy.2018.8.e6
Abstract
- BACKGROUND
The basophil activation test (BAT) is a promising tool for monitoring allergen-specific immunotherapy responses.
OBJECTIVE
We aimed to investigate the changes in basophil activation in response to the inhalant allergens of house dust mite (HDM) and mugwort pollen during immunotherapy in patients with allergic rhinitis.
METHODS
We enrolled patients with allergic rhinitis who were to receive subcutaneous immunotherapy for the inhalant allergens HDM or mugwort. A BAT was performed to assess CD63 upregulation in response to allergen stimulation using peripheral blood collected from the patients prior to immunotherapy and at 3, 6, 12, and 24 months after beginning immunotherapy. Rhinitis symptoms were evaluated using the rhinitis quality of life questionnaire (RQLQ) at 1-year intervals.
RESULTS
Seventeen patients (10 with HDM sensitivity, 3 with mugwort sensitivity, and 4 with sensitivity to both HDM and mugwort) were enrolled in the study. Basophil reactivity to HDM did not change significantly during 24 months of immunotherapy. However, a significant reduction in basophil reactivity to mugwort was observed at 24-month follow-up. There was no significant association between the change in clinical symptoms by RQLQ and the change in basophil reactivity to either allergen. The change in allergen-specific basophil reactivity to HDM was well correlated with the change in nonspecific basophil activation induced by anti-FcεRI antibody, although basophil reactivity to anti-FcεRI antibody was not significantly reduced during immunotherapy.
CONCLUSION
Suppression of CD63 upregulation in the BAT was only observed with mugwort at 2-year follow-up. However, the basophil response did not reflect the clinical response to immunotherapy.
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