Cancer Res Treat.  2018 Oct;50(4):1452-1457. 10.4143/crt.2017.414.

Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review

• Zhu P
• Duan Y
• Ao Q
• Wang G

• KMID: 2424815
• DOI: http://doi.org/10.4143/crt.2017.414

Abstract

Microcystic stromal tumor (MCST) is a rare subtype of sex cord-stromal neoplasm. Tumors from all 31 previously reported cases were located in the ovary. Herein, we present a unique case of a right-side testicular tumor in a 33-year-old Chinese male. The tumor is composed of predominantly lobulated cellular nodules separated by hyalinized fibrous stroma and they expressed CD10, β-catenin (nuclear), and cyclin D1. Molecular analysis identified a point mutation (c.110C>G) in exon 3 of CTNNB1. The histopathological features, immunohistochemistry profiles, and molecular analysis of this tumor were consistent with MCST of the ovary. Therefore, a diagnosis of MCST of the right testicle was determined. To the best of our knowledge, this is the first case of MCST occurring in the testicles. The study may provide new insights to the tumor biology of MCST and a better understanding of this rare entity.

Keyword

Microcystic stromal tumor; Testis; CTNNB1

MeSH Terms

Adult
Asian Continental Ancestry Group
Biology
Cyclin D1
Diagnosis
Exons
Female
Humans
Hyalin
Immunohistochemistry
Male
Ovary
Point Mutation
Testis*
Cyclin D1

Figure

• 

  Fig. 1. Images of the tumor. Computed tomography showed a 3-cm solid-cystic mass in the right testicle.

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  Fig. 2. Histology and immunohistochemistry of the tumor. (A) Histologically the tumor was well-circumscribed in the testicle, and exhibited typically lobulated cellular regions separated by hyaline bands and fibrous plaques and multiple microcystic changes at the low power field (H&E staining, ×40). (B) The tumor cells showed uniform, small, round to ovoid nuclei with inconspicuous nucleoli in high-power views, and there was no nuclear atypia, and mitotic activity is low (H&E staining, ×200). (C) Immunostaining reveals the tumor cells are positive for vimentin (×200). (D) Immunostaining reveals the tumor cells are positive for CD10 (×200). (E) The tumor showed diffuse and strong nuclear immunoreactivity for β-catenin (×200). (F) The tumor showed diffuse and strong nuclear immunoreactivity for cyclin D1 (×200).

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  Fig. 3. Molecular analysis of the tumor. Sequence chromatogram of the case harboring point mutation in exon 3 of CTNNB1 (c.110C>G).

Reference

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