Yonsei Med J.  2018 Nov;59(9):1015-1025. 10.3349/ymj.2018.59.9.1015.

Bioactive Compounds for the Treatment of Renal Disease

• Cho KS
• Ko IK
• Yoo JJ

• KMID: 2422485
• DOI: http://doi.org/10.3349/ymj.2018.59.9.1015

Abstract

Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. To overcome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During the past decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts, studies on renal cell therapy and artificial kidney developments have been conducted, and multiple therapeutic interventions have shown promise in the pre-clinical and clinical settings. More recently, therapeutic cell-secreting secretomes have emerged as a potential alternative to cell-based approaches. This approach involves the use of renotropic factors, such as growth factors and cytokines, that are produced by cells and these factors have shown effectiveness in facilitating kidney function recovery. This review focuses on the renotropic functions of bioactive compounds that provide protective and regenerative effects for kidney tissue repair, based on the available data in the literature.

Keyword

Acute kidney injury; kidney failure; chronic; tissue engineering; regenerative medicine

MeSH Terms

Acute Kidney Injury
Cell- and Tissue-Based Therapy
Cytokines
Developmental Biology
Dialysis
Intercellular Signaling Peptides and Proteins
Kidney
Kidney Diseases
Kidney Transplantation
Kidneys, Artificial
Recovery of Function
Regenerative Medicine
Renal Insufficiency
Renal Insufficiency, Chronic
Stem Cells
Tissue Engineering
Cytokines
Intercellular Signaling Peptides and Proteins