J Vet Sci.  2018 May;19(3):468-471. 10.4142/jvs.2018.19.3.468.

Identification and characterization of atypical porcine pestivirus genomes in newborn piglets with congenital tremor in China

• Shen H
• Liu X
• Zhang P
• Wang L
• Liu Y
• Zhang L
• Liang P
• Song C

• KMID: 2412138
• DOI: http://doi.org/10.4142/jvs.2018.19.3.468

Abstract

Recently, a novel atypical porcine pestivirus (APPV) in pig was reported. In this study, two APPV strains, APPV-China/GZ01/2016 (GZ01) and APPV-China/GD-SD/2016 (GD-SD), were identified in two newborn piglet herds with congenital tremor from China. The open reading frame of the two strains shared an 83.5% nucleotide identity. Phylogenetically, the APPV strains were placed into two groups: GZ01 belonged to group I and GD-SD belonged to group II. A high viral load was detected in the cerebellum (quantification cycles < 26). Further studies should be carried out to thoroughly elucidate the development of congenital tremors caused by APPV.

Keyword

atypical porcine pestivirus; congenital tremor; virus characterization

MeSH Terms

Cerebellum
China*
Genome*
Humans
Infant, Newborn*
Open Reading Frames
Pestivirus*
Tremor*
Viral Load