Psychiatry Investig.  2018 Apr;15(4):407-412. 10.30773/pi.2017.06.17.1.

Correlations of Four Genetic Single Nucleotide Polymorphisms in Brain-Derived Neurotrophic Factor with Posttraumatic Stress Disorder

Affiliations
  • 1Department of Science and Education, Hainan General Hospital, Hainan, China.
  • 2Department of Science and Education, Affiliated Hainan Hospital of Nanhua University, Hainan, China.
  • 3Hainan Province, Haikou People's Hospital, Hospital Dean's Office, Hainan, China.
  • 4The Psychological Research Center of Hainan General Hospital, Hainan, China. minguodoc@126.com
  • 5School of Public Health, Hainan Medical College, Hainan, China.
  • 6Department of Equipment, Hainan General Hospital, Hainan, China.
  • 7Department of Psychology, Hainan General Hospital, Hainan, China.
  • 8Department of Clinical Laboratory, Hainan General Hospital, Hainan, China.
  • 9Medical Center, Hainan General Hospital, Hainan, China.

Abstract

OBJECTIVE: To investigate the correlations of four genetic single nucleotide polymorphisms (SNPs) of brain-derived neurotrophic factor (BDNF) with posttraumatic stress disorder (PTSD).
METHODS
A total of 300 patients with sporadic PTSD and 150 healthy subjects (the control group) were selected according to the diagnostic criteria of PTSD (DSM-IV), and the genotypes of the BDNF SNPs G-712A, C270T, rs6265, and rs7103411 were detected by polymerase chain reaction and direct DNA sequencing to determine intergroup differences in the genotypes and allele frequencies; the p values were corrected with the permutation test.
RESULTS
The genotypes and allele frequencies of the SNPs G-712A, rs6265, and rs7103411 of BDNF showed no significant intergroup differences (p>0.05). However, the genotype and allele frequencies of C270T showed significant differences between the PTSD group and the control group (p<0.05).
CONCLUSION
The SNP C270T of BDNF may be associated with PTSD. Individuals carrying the polymorphic T allele of C270T may be more likely to suffer from PTSD.

Keyword

Brain-derived neurotrophic factor; Posttraumatic stress disorder; Gene polymorphism
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