Clin Nutr Res.  2018 Apr;7(2):126-135. 10.7762/cnr.2018.7.2.126.

Hypouricemic Effect of Ethanol Extract of Aster glehni Leaves in Potassium Oxonate-Induced Hyperuricemic Rats

Affiliations
  • 1Department of Public Health Science (Brain Korea 21 PLUS Program), Graduate School, Korea University, Seoul 02841, Korea. yhlim@korea.ac.kr
  • 2Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul, 02841, Korea.
  • 3Research and Development Center, Milae Resources ML Co. Ltd., Seoul 05542, Korea.
  • 4Department of R&D, Koreaeundan Co., Seongnam 06105, Korea.
  • 5Bioland Co. Ltd., Ansan 15407, Korea.
  • 6Department of Laboratory Medicine, Korea University Guro Hospital, Seoul 08308, Korea.

Abstract

The prevalence of gout is increasing worldwide, and control of serum uric acid level has been regarded as one of the therapeutic methods for gout. Inhibition of xanthine oxidase (XO) activity which can oxidize hypoxanthine to uric acid has been commonly proposed to decrease serum uric acid level. The aim of this study was to demonstrate the hypouricemic effect of ethanol extract of Aster glehni leaves (EAG) by in vitro and in vivo study in potassium oxonate (PO)-induced hyperuricemic rats. EAG possessed 132.5 ± 6.8 mg QE/g of total flavonoid and showed antioxidant activity. EAG showed in vitro and in vivo inhibitory activity against XO and significantly decreased serum uric acid level in PO-induced hyperuricemic rats without liver toxicity. These results show that EAG significantly attenuates hyperuricemia by inhibiting XO activity, which resulted in the decrease of serum uric acid level. Therefore, EAG might possess a potential therapeutic ability for improving gout.

Keyword

Aster glehni; Hyperuricemia; Xanthine oxidase; Serum uric acid
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