Mycobiology.
2012 Mar;40(1):42-46.
Isolation, Identification and Characterization of a Antidementia Acetylcholinesterase Inhibitor-Producing Yarrowia lipolytica S-3
- Affiliations
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- 1Department of Life Science and Genetic Engineering, PaiChai University, Daejeon 302-735, Korea. biotech8@pcu.ac.kr
- 2Department of Bio-Environmental Chemistry, Chungnam National University, Daejeon 305-764, Korea.
- 3Microbial and Enzymatic Technology Group, Bioprocess Platform, Biotechnology Research Institite, National Research Council of Canada, Montreal, QC H4P2R2, Canada.
Abstract
- This report describes the isolation and identification of a potent acetylcholinesterase (AChE) inhibitor-producing yeasts. Of 731 species of yeast strain, the S-3 strain was selected as a potent producer of AChE inhibitor. The selected S-3 strain was investigated for its microbiological characteristics. The S-3 strain was found to be short-oval yeast that did not form an ascospore. The strain formed a pseudomycelium and grew in yeast malt medium containing 50% glucose and 10% ethanol. Finally, the S-3 strain was identified by its physiological characteristics and 26S ribosomal DNA sequences as Yarrowia lipolytica S-3.
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