Mycobiology.  2009 Sep;37(3):203-206. 10.4489/MYCO.2009.37.3.203.

Nutritional and Physicochemical Characteristics of the Antidementia Acetylcholinesterase-Inhibiting Methanol Extracts from Umbilicaria esculenta

  • 1Department of Life Science and Genetic Engineering, Paichai University, Daejeon 302-735, Korea.
  • 2Department of Emergency Medical Technology, Woosong University, Daejeon 300-718, Korea.


To develop new antidementia nutraceuticals, a potent acetylcholinesterase (AChE)-inhibiting extract was screened from various extracts of nutritional mushrooms and lichens nutritional and its physicochemical properties were investigated. Among the several extracts tested, methanol extracts of Umbilicaria esculenta fruiting body showed the highest AChE inhibitory activity of 22.4%. U. esculenta AChE inhibitor was maximally extracted when fruiting bodies were treated with 80% methanol at 40degrees C for 18 h. The methanol extracts contained 18.9% crude lipid, 18.8% crude protein, and 11.6% total sugar. In addition, they contained 444 mg/g glutamic acid, 44 mg/g histidine, and 41 mg/g aspartic acid. The methanol extracts were soluble in a solution of methanol and 20% dimethylsulfoxide, insoluble in n-hexane, chloroform, and water, and were stable at 20~60degrees C and pH 1.0~5.0 for 1 h.


Antidementia; Acetylcholinesterase inhibitor; Umbilicaria esculenta
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