Korean Circ J.  2018 Mar;48(3):227-229. 10.4070/kcj.2018.0003.

Emerging Role of Aldosterone in Mediating the Vicious Cycle of Obesity, Insulin Resistance and Metabolic Syndrome

Affiliations
  • 1Division of Cardiology, Severance Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea. shpark0530@yuhs.ac

Abstract

No abstract available.


MeSH Terms

Aldosterone*
Insulin Resistance*
Insulin*
Negotiating*
Obesity*
Aldosterone
Insulin

Reference

1. Conn JW. Hypertension, the potassium ion and impaired carbohydrate tolerance. N Engl J Med. 1965; 273:1135–1143. PMID: 5841677.
2. Sowers JR, Whaley-Connell A, Epstein M. Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension. Ann Intern Med. 2009; 150:776–783. PMID: 19487712.
3. Luther JM. Effects of aldosterone on insulin sensitivity and secretion. Steroids. 2014; 91:54–60. PMID: 25194457.
4. Selvaraj J, Sathish S, Mayilvanan C, Balasubramanian K. Excess aldosterone-induced changes in insulin signaling molecules and glucose oxidation in gastrocnemius muscle of adult male rat. Mol Cell Biochem. 2013; 372:113–126. PMID: 23007523.
5. Yamashita R, Kikuchi T, Mori Y, et al. Aldosterone stimulates gene expression of hepatic gluconeogenic enzymes through the glucocorticoid receptor in a manner independent of the protein kinase B cascade. Endocr J. 2004; 51:243–251. PMID: 15118277.
6. Lastra G, Whaley-Connell A, Manrique C, et al. Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat. Am J Physiol Endocrinol Metab. 2008; 295:E110–E116. PMID: 18445755.
7. Goodfriend TL, Ball DL, Egan BM, Campbell WB, Nithipatikom K. Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion. Hypertension. 2004; 43:358–363. PMID: 14718355.
8. Catena C, Lapenna R, Baroselli S, et al. Insulin sensitivity in patients with primary aldosteronism: a follow-up study. J Clin Endocrinol Metab. 2006; 91:3457–3463. PMID: 16822818.
9. Wu VC, Chueh SJ, Chen L, et al. Risk of new-onset diabetes mellitus in primary aldosteronism: a population study over 5 years. J Hypertens. 2017; 35:1698–1708. PMID: 28661412.
10. Kumagai E, Adachi H, Jacobs DR Jr, et al. Plasma aldosterone levels and development of insulin resistance: prospective study in a general population. Hypertension. 2011; 58:1043–1048. PMID: 22068870.
11. Min SH, Kim SH, Jeong IK, et al. Independent association of serum aldosterone level with metabolic syndrome and insulin resistance in Korean adults. Korean Circ J. 2018; 48:198–208. PMID: 29557106.
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