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Molecular Mechanisms of Primary Aldosteronism

Tevosian S, Fox SC, Ghayee HK

Primary aldosteronism (PA) results from excess production of mineralocorticoid hormone aldosterone by the adrenal cortex. It is normally caused either by unilateral aldosterone-producing adenoma (APA) or by bilateral aldosterone excess...
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Aldosterone Rapidly Enhances Levels of the Striatin and Caveolin-1 Proteins in Rat Kidney: The Role of the Mineralocorticoid Receptor

Inthachart K, Manotham K, Eiam-Ong S, Eiam-Ong S

BACKGROUND: Striatin and caveolin-1 (cav-1) are scaffolding/regulating proteins that are associated with salt-sensitive high blood pressure and promote renal sodium and water reabsorption, respectively. The mineralocorticoid receptor (MR) interacts with...
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Hypertension secondary to renal hypoplasia presenting as acute heart failure in a newborn

Deitrick J, Stevenson , Nguyen D, Sessions W, Linga V, Vasylyeva

INTRODUCTION: Neonatal hypertension is defined as persistent systolic and/or diastolic blood pressures above the 95th percentile compared to other infants of similar gestational age and size. Neonatal hypertension is a...
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Estrogen-secreting adrenocortical carcinoma

Jeong Y, Cho SC, Cho HJ, Song JS, Kong JS, Park JW, Ku YH

Adrenocortical carcinoma is a rare type of endocrine malignancy with an annual incidence of approximately 1–2 cases per million. The majority of these tumors secrete cortisol, and a few secrete...
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Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism

Lim JS, Hong N, Park S, Park SI, Oh YT, Yu MH, Lim PY, Rhee Y

BACKGROUND: Increasing evidence supports interplay between aldosterone and parathyroid hormone (PTH), which may aggravate cardiovascular complications in various heart diseases. Negative structural cardiovascular remodeling by primary aldosteronism (PA) is also...
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Primary Aldosteronism and Cerebrovascular Diseases

Chen ZW, Hung CS, Wu VC, Lin YH, the TAIPAI study group

As diagnostic techniques have advanced, primary aldosteronism (PA) has emerged as the most common cause of secondary hypertension. The excess of aldosterone caused by PA resulted in not only cardiovascular...
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A Case of Infantile Nephrotic Syndrome associated with Neuroblastoma

Kim SH, Park HM, Lee JH, Kim H, Go H, Kim DY, Park YS

Nephrotic syndrome in the first year of life, characterized by renal dysfunction and proteinuria, is associated with a heterogeneous group of disorders. These disorders are often related to genetic mutations,...
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Update on the Aldosterone Resolution Score and Lateralization in Patients with Primary Aldosteronism

Cho EH

No abstract available.
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Characteristics of Adrenal Incidentalomas in a Large, Prospective Computed Tomography-Based Multicenter Study: The COAR Study in Korea

Ahn SH, Kim JH, Baek SH, Kim H, Cho YY, Suh S, Kim BJ, Hong S, Koh JM, Lee SH, Song KH

PURPOSE: Previous studies on adrenal incidentalomas (AIs) are limited by their retrospective design, small numbers of patients, Western populations, or use of an outdated imaging technique. We investigated the characteristics...
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Emerging Role of Aldosterone in Mediating the Vicious Cycle of Obesity, Insulin Resistance and Metabolic Syndrome

Park S

No abstract available.
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Independent Association of Serum Aldosterone Level with Metabolic Syndrome and Insulin Resistance in Korean Adults

Min SH, Kim SH, Jeong IK, Cho HC, Jeong JO, Lee JH, Kang HJ, Kim HS, Park KS, Lim S

BACKGROUND AND OBJECTIVES: A relationship between renin-angiotensin system (RAS) components and metabolic syndrome (MetS) has been suggested, but not elucidated clearly. We examined the levels of RAS components in patients...
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Renin dependent hypertension caused by accessory renal arteries

Chan PL, Tan FH

BACKGROUND: Hypokalemia in the presence of hypertension is often attributed to primary hyperaldosteronism as a cause of secondary hypertension, however secondary hyperaldosteronism may present similarly. Accessory renal arteries are variants...
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Renal intercalated cells and blood pressure regulation

Wall SM

Type B and non-A, non-B intercalated cells are found within the connecting tubule and the cortical collecting duct. Of these cell types, type B intercalated cells are known to mediate...
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Antihypertensive effect of Ganjang (traditional Korean soy sauce) on Sprague-Dawley Rats

Mun EG, Sohn HS, Kim MS, Cha YS

BACKGROUND/OBJECTIVES: Although Korean fermented foods contain large amounts of salt, which is known to exacerbate health problems, these foods still have beneficial effects such as anti-hypertension, anti-cancer, and anti-colitis properties....
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CTNNB1 Mutation in Aldosterone Producing Adenoma

Wang JJ, Peng KY, Wu VC, Tseng FY, Wu KD

Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs) with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1) mutation in APAs has been recently described...
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Implications of Plasma Renin Activity and Plasma Aldosterone Concentration in Critically Ill Patients with Septic Shock

Chung KS, Song JH, Jung WJ, Kim YS, Kim SK, Chang J, Park MS

BACKGROUND: The renin-angiotensin-aldosterone system is closely associated with volume status and vascular tone in septic shock. The present study aimed to assess whether plasma renin activity (PRA) and plasma aldosterone...
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Differences in left ventricular functional adaptation to arterial stiffness and neurohormonal activation in patients with hypertension: a study with two-dimensional layer-specific speckle tracking echocardiography

Kim D, Shim CY, Hong GR, Park S, Cho I, Chang HJ, Ha JW, Chung N

BACKGROUND: Arterial stiffness increases pressure load to the left ventricle (LV), leading to LV hypertrophy and subendocardial ischemia. Neurohormones stimulate myocardial fibrosis and LV dysfunction. We aimed to explore the...
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Unmasked chronic renal function deterioration after unilateral adrenalectomy in patients with primary aldosteronism

Park SM, Jung WJ, Park JM, Rhee H, Kim IY, Seong EY, Lee DW, Lee SB, Kwak IS, Shin N, Song SH

We report 2 cases of chronic estimated glomerular filtration rate (eGFR) decline after unilateral adrenalectomy due to primary aldosteronism. The patients were diagnosed with unilateral adrenal cortical adenoma releasing aldosterone....
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17α-hydroxylase Deficiency Mimicking Hyperaldosteronism by Aldosterone-producing Adrenal Adenoma

Cho YK, Oh H, Kang SM, An S, Huh JY, Lee JH, Lee WJ

17α-hydroxylase deficiency is a rare cause of congenital adrenal hyperplasia and is characterized by primary amenorrhea, delayed puberty and hypertension. Although 17α-hydroxylase deficiency mimics mineralocorticoid-induced hypertension, impaired sexual development can...
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Refractory and Resistant Hypertension: Antihypertensive Treatment Failure versus Treatment Resistance

Calhoun DA

Resistant hypertension has for many decades been defined as difficult-to-treat hypertension in order to identify patients who may benefit from special diagnostic and/or therapeutic considerations. Recently, the term "refractory hypertension"...
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