Clin Psychopharmacol Neurosci.  2018 Feb;16(1):109-113. 10.9758/cpn.2018.16.1.109.

Limbic Encephalitis Manifesting as Selective Amnesia and Seizure-like Activity: A Case Report

Affiliations
  • 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea. anton3@catholic.ac.kr
  • 2Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

Limbic encephalitis (LE) is characterized by short-term memory loss, disorientation, agitation, seizures, and histopathological evidence of medial temporal lobe inflammation. Leucine-rich, glioma inactivated 1 (LGI-1) is an auto-antigen associated with LE. We report a 37-year-old male patient with LGI-1-related LE who presented with recurrent episodes of selective amnesia, seizure-like activity, confusion, and personality change. His symptoms were significantly improved with steroid therapy. Thorough differential diagnosis with consideration for autoimmune encephalitis should be in patients with presentation of symptoms, such as memory impairment, personality change and seizure-like activity, especially when other neurological diagnoses are excluded.

Keyword

Anti-LGI-1 antibody encephalitis; Neuropsychiatric symptoms; Steroid therapy
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