Cancer Res Treat.  2018 Jan;50(1):88-94. 10.4143/crt.2016.494.

Re-stratification of Patients with High-Risk Prostate Cancer According to the NCCN Guidelines among Patients Who Underwent Radical Prostatectomy: An Analysis Based on the K-CaP Registry

• Lee KS
• Koo KC
• Choi IY
• Lee JY
• Hong JH
• Kim CS
• Lee HM
• Hong SK
• Byun SS
• Rha KH
• Chung BH

• KMID: 2403477
• DOI: http://doi.org/10.4143/crt.2016.494

Abstract

PURPOSE
The present study aimed to re-stratify patients with high-risk prostate cancer according to the National Comprehensive Cancer Network guidelines among patients who underwent radical prostatectomy (RP).
MATERIALS AND METHODS
This study used the Korean Prostate Cancer Database registry and identified 1,060 patients with high-risk prostate cancer who underwent RP between May 2001 and April 2013. All patients were categorized into risk groups, and subgroups were identified according to the type and number of high-risk factors.
RESULTS
Of the 1,060 high-risk patients, 599 (56.5%), 408 (38.5%), and 53 (5.0%) had 1, 2, and 3 risk factors, respectively. In multivariate analysis, the Gleason score, percentage of positive biopsy cores, and number of risk factors present were identified as independent predictors of biochemical recurrence. There were significant differences in the 5-year postoperative biochemical failure-free survival (BCFFS) rate among the different high-risk factor subgroups (log-rank p < 0.001). There were no significant differences in the BCFFS rate between the subgroup of high-risk patients with a prostate-specific antigen level > 20 ng/mL alone and the intermediate-risk group with all factors (log-rank p=0.919 and p=0.781, respectively). Additionally, no significant difference was noted in the BCFFS rate between high-risk patients having all factors and those in the very-high-risk group (p=0.566).
CONCLUSION
We successfully re-stratified patients with high-risk prostate cancer and identified the combinations of high-risk criteria that will help in the selection of patients for RP.

Keyword

Prostatic neoplasms; Prostatectomy; Risk assessment

MeSH Terms

Biopsy
Humans
Multivariate Analysis
Neoplasm Grading
Prostate*
Prostate-Specific Antigen
Prostatectomy*
Prostatic Neoplasms*
Recurrence
Risk Assessment
Risk Factors
Prostate-Specific Antigen

Figure

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  Fig. 1. Biochemical recurrence (BCR) in the very-low-risk, low-risk, intermediate-risk, high-risk, very-high-risk, and metastatic-risk groups.

Reference

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