Yeungnam Univ J Med.  2017 Dec;34(2):270-274. 10.12701/yujm.2017.34.2.270.

Double primary lung adenocarcinoma diagnosed by epidermal growth factor receptor mutation status

  • 1Department of Internal Medicine, Konyang University Hospital, Daejeon, Korea.
  • 2Department of Pathology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Daegu, Korea.
  • 3Department of Pathology, Konyang University Hospital, Daejeon, Korea.
  • 4Department of Thoracic Surgery, Konyang University Hospital, Daejeon, Korea.


A nodular density was detected on a chest radiograph taken from a 57-year-old Korean woman who was visiting a hospital for a routine check. Chest computed tomography revealed a 4.8 cm lobulated mass in the right lung and another focal nodular lesion in the left lung; biopsies of both lungs revealed adenocarcinoma. We conducted DNA sequencing and peptide nucleic acid clamping to investigate the potential double primary lung cancer. The results verified that the mass in the right lung had a mutation in the epidermal growth factor receptor, whereas the nodule in the left lung had a wild-type sequence, showing that these two were genetically different cancers from one another. Thus, we demonstrate that genetic testing is useful in determining double primary lung cancer, and we herein report on this case.


Adenocarcinoma; Differential diagnosis; Lung cancer; DNA sequence analysis; Mutations
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