Korean J Intern Med.  2017 Nov;32(6):1082-1089. 10.3904/kjim.2015.322.

The role of ¹⁸F-fluorodeoxyglucose positron emission tomography in the assessment of disease activity of adult-onset Still’s disease

• An YS
• Suh CH
• Jung JY
• Cho H
• Kim HA

• KMID: 2396769
• DOI: http://doi.org/10.3904/kjim.2015.322

Abstract

BACKGROUND/AIMS
¹â¸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹â¸F-FDG PET/CT) has been suggested as a reliable imaging technique for monitoring of disease activity in patients with adult-onset Still's disease (AOSD). Therefore, we investigated the clinical significance of ¹â¸F-FDG PET/CT in Korean AOSD patients.
METHODS
Thirteen AOSD patients were included in the study. The PET/CT images were evaluated with visual and semiquantitative method using standardized uptake values (SUVs).
RESULTS
The presence of increased ¹â¸F-FDG uptake was noted in 90% of clinically active AOSD patients. ¹â¸F-FDG uptake was located in the lymph node, spleen, and bone marrow. Visual grade and SUV intensity of lymph node was significantly correlated with the systemic score of AOSD. Visual grade of spleen was significantly correlated with the systemic score, erythrocyte sedimentation rate (ESR), and ferritin. Additionally, visual grade and SUV intensity of bone marrow was significantly correlated with the systemic score, ESR, leukocyte, and neutrophil.
CONCLUSIONS
Visual grade and SUV intensity of lymph node, spleen, and bone marrow on ¹â¸F-FDG PET/CT scan showed significant correlations with known disease activity markers. The data suggest that ¹â¸F-FDG PET/CT scan may be a useful imaging technique for evaluation of disease activity in AOSD patients.

Keyword

Still’s disease, adult-onset; ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography; Disease activity

MeSH Terms

Blood Sedimentation
Bone Marrow
Electrons*
Ferritins
Humans
Leukocytes
Lymph Nodes
Methods
Neutrophils
Positron-Emission Tomography and Computed Tomography
Positron-Emission Tomography*
Spleen
Ferritins