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The Significance of p-AKT1 as a Prognostic Marker and Therapeutic Target in Patients With Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor-2-Positive Early Breast Cancer

Kim JY, Park CS, Jang SK, Seol H, Seong MK, Noh WC, Park IC, Kim HA

Purpose: Phosphorylated AKT1 (p-AKT1) at Ser473 is a functional isoform of AKT and a key component of the PI3K/mTOR/AKT pathway. This study aimed to evaluate the prognostic significance of p-AKT1...
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Pear pomace alleviated atopic dermatitis in NC/Nga mice and inhibited LPS-induced inflammation in RAW 264.7 macrophages

You M, Wang Z, Kim HJ, Lee YH, Kim HA

BACKGROUND/OBJECTIVES: Poorly regulated inflammation is believed to be the most predominant factor that can result in a wide scope of diseases including atopic dermatitis (AD). Despite many studies on the...
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Abnormal Development of Neural Stem Cell Niche in the Dentate Gyrus of Menkes Disease

Cho Sk, Gwon S, Kim HA, Kim J, Cho SY, Kim DE, Chae JH, Park DH, Hwang YK

Background and Objectives: Menkes disease (MNK) is a rare X-linked recessive disease, caused by mutations in the copper transporting ATP7A gene that is required for copper homeostasis. MNK patients experience...
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Healthcare Workforce Response to The Coronavirus Disease Outbreak in Daegu, Korea: A Multi-Center, Cross-Sectional Survey

Kwon HH, Kim HI, Kwon KT, Hwang S, Kim SW, Kim Y, Kim Ha, Hyun M, Hong HL, Kim MJ, Hur J, Hong KS

Background: Securing an available healthcare workforce is critical to respond to coronavirus disease 2019 (COVID-19); however, research investigating Korea’s COVID-19 staffing response is rare. To present the fundamental data of...
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Clinical Characteristics and Risk Factors for Mortality in Critical Coronavirus Disease 2019 Patients 50 Years of Age or Younger During the Delta Wave: Comparison With Patients > 50 Years in Korea

Shi HJ, Nham E, Kim B, Joo EJ, Cheong HS, Hong SH, Hyun M, Kim Ha, Jang S, Rhee JY, Kim J, Kim S, Cho HK, Wi YM, Cheon S, Kim YS, Lim S, Seok H, Jung SI, Eom JS, Peck KR

Background: Numerous patients around the globe are dying from coronavirus disease 2019 (COVID-19). While age is a known risk factor, risk analysis in the young generation is lacking. The present...
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Diagnostic Value of Anti-Nuclear Antibodies: Results From Korean University-Affiliated Hospitals

Kang SH, Seo YI, Lee MH, Kim HA

Background: Unnecessary and inappropriate laboratory testing accounts for a significant portion of waste in health care utilization. The aim of this study was to examine the diagnostic value of the...
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Risk Factors for Coronavirus Disease 2019 (COVID-19)-Associated Pulmonary Aspergillosis in Critically Ill Patients: A Nationwide, Multicenter, Retrospective Cohort Study

Kim SH, Hong JY, Bae S, Lee H, Wi YM, Ko JH, Kim B, Joo EJ, Seok H, Shi HJ, Yoo JR, Hyun M, Kim Ha, Jang S, Mun SJ, Kim J, Kim MC, Jung DS, Kim SH, Peck KR

Background: Coronavirus disease 2019 (COVID-19) is often accompanied by secondary infections, such as invasive aspergillosis. In this study, risk factors for developing COVID-19-associated pulmonary aspergillosis (CAPA) and their clinical outcomes...
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The Prediction of HER2-Targeted Treatment Response Using 64CuTetra- Azacyclododecanetetra-Acetic Acid (DOTA)-Trastuzumab PET/CT in Metastatic Breast Cancer: A Case Report

Lee I, Lim I, Byun BH, Kim BI, Choi CW, Lee KC, Kang CM, Seong MK, Kim HA, Noh WC, Lim SM

A 45-year-old woman diagnosed with breast cancer reported disease progression in the form of metastatic lung and recurrent breast lesions following chemotherapy and human epidermal growth factor receptor 2 (HER2)-targeted...
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Effects of Lipopolysaccharide on Oligodendrocyte Differentiation at Different Developmental Stages: an In Vitro Study

Ahn JH, Lee HJ, Lee K, Lim J, Hwang JK, Kim CR, Kim HA, Kim HS, Park HK

Background: Lipopolysaccharide (LPS) exerts cytotoxic effects on brain cells, especially on those belonging to the oligodendrocyte lineage, in preterm infants. The susceptibility of oligodendrocyte lineage cells to LPS-induced inflammation is...
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Arthroscopic Partial Meniscectomy versus Physical Therapy for Degenerative Meniscal Tear: a Systematic Review

Choi M, Lee SJ, Park CM, Ryoo S, Kim S, Jang JY, Kim HA

Background: Meniscal tears are commonly observed in patients with knee osteoarthritis (OA), however, clinical significance of such lesions detected by magnetic resonance imaging is in many cases unclear. This study...
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The use of implant-assisted removable partial denture in the partially edentulous maxilla with a few unilateral remaining teeth and implant overdenture in the mandible: A case report

Yun Y, Kim HA, Park S, Park C, Jang W

Successful cases of the implant-assisted removable partial denture and implant overdentures are reported in which a few implants are additionally placed to secure the maintenance, support, and stability of the...
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KOBIO, the First Web-based Korean Biologics Registry Operated With a Unified Platform Among Distinct Disease Entities

Kim J, Koh JH, Choi SJ, Jeon CH, Kwok SK, Kim SK, Choi CB, Lee J, Lee C, Nam EJ, Park YB, Lee SS, Kim TH, Park SH, Choe JY, Koh EM, Yoo DH, Song YW, Kim HA, Shin K

The KOrean College of Rheumatology BIOlogics and targeted therapy (KOBIO) registry is a nationwide observational cohort that captures detailed data on exposure of patients to biologic and targeted synthetic disease-modifying...
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An Unusual Case of Aortic and Mitral Valve Involved Erysipelothrix rhusiopathiae-Induced Endocarditis: Rare Zoonosis with Devastating Outcome

Oh BK, Kim HA, Lee SJ, Lee SH, Lee JY, Kim BJ, Kim BS, Kang JH, Kim Jw, Choi HI, Sung KC

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Hemorrhagic Retinal Macrocyst with Retinal Detachment

Han YE, Kim HA, Kim JG

Purpose: To report a satisfactory clinical outcome of hemorrhagic retinal macrocyst with retinal detachment after pars plana vitrectomy and silicone oil injection. Case summary: A 33-year-old man visited our clinic...
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Analysis of PC20-FEF25%-75% and △FVC in the methacholine bronchial provocation test

Kim HA, Kwon JE, Ahn JY, Choe JY, Kim DS, Park SH, Hyun MC, Choi BS

Purpose: Forced expiratory flow between 25% and 75% (FEF 25%-75%) is known to sensitively reflect bronchial obstruction. Methacholine challenge test (MCT) has shown varying reduction levels of forced vital capacity...
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A Mixed Method Study for Exploring the Difficulties in End-of-Life Care and End-of-Life Care Competency in Nurses Who Take Care of Cancer Patients

Kim LH, Kim SY, Kim S, Kim HA, Yang HJ, Lee KM, Lee SY, Lee KH, Kim JH

Purpose: This study investigated the difficulties in end-of-life care and end-of-life care competency in nurses who take care of cancer patients. Methods: In the mixed method, a structured questionnaire on...
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Intractable Coronary Spasm Requiring Percutaneous Coronary Intervention after Coronary Artery Bypass Grafting in a Patient with Moyamoya Disease

Kim HA, Kim YS, Kim WS

Moyamoya disease (MMD) is characterized by progressive steno-occlusive lesions of the distal or proximal branch of the internal carotid arteries, and cerebrovascular symptoms are its major complications. Extracranial vascular involvement...
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Health-related Quality of Life Outcomes of Adalimumab for Patients With Rheumatoid Arthritis in Korea

Lee Ms, Lee CH, Lee HS, Sung YK, Choi JR, Park K, Lim MK, Choi BY, Kim HA, Choi SW, Lee Y, Yoo WH

Objective: Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune disorder that impairs patients’ overall health-related quality of life (HRQOL). In this study, we evaluated the effect of adalimumab in Korean...
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Diffuse Cerebellar Dysfunction as a Permanent Neurological Sequela of Organophosphate Poisoning: A Case Report

Kim HA, Lee H

The diffuse cerebellar dysfunction as a permanent neurological sequela of organophosphate poisoning has not yet been reported in the published literature. We report a diffuse cerebellar dysfunction as a permanent...
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Implementation of Venoarterial Extracorporeal Membrane Oxygenation in Nonintubated Patients

Kim HA, Kim YS, Cho YH, Kim WS, Sung K, Jeong DS

Background: Although extracorporeal membrane oxygenation (ECMO) is generally performed percutaneously, the technology is deployed under sedation and necessitates endotracheal intubation. However, in some patients, the use of venoarterial (VA) ECMO...
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